Rich-Club Organization Disturbances of the Individual Morphological Network in Subjective Cognitive Decline

被引:7
|
作者
Peng, Liling [1 ]
Feng, Jing [2 ]
Ma, Di [3 ]
Xu, Xiaowen [4 ]
Gao, Xin [1 ]
机构
[1] Shanghai Univ Med Imaging Diagnost Ctr, Shanghai, Peoples R China
[2] Fifth Peoples Hosp Jinan, Jinan, Peoples R China
[3] Nanjing Forestry Univ, Coll Informat Sci & Technol, Nanjing, Peoples R China
[4] Tongji Univ, Sch Med, Tongji Hosp, Dept Med Imaging, Shanghai, Peoples R China
来源
基金
中国国家自然科学基金;
关键词
subjective cognitive decline; rich-club; Alzheimer's disease; morphological network; gray matter (GM); HUMAN CONNECTOME; COST;
D O I
10.3389/fnagi.2022.834145
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
BackgroundSubjective cognitive decline (SCD) was considered to be the preclinical stage of Alzheimer's disease (AD). However, less is known about the altered rich-club organizations of the morphological networks in individuals with SCD. MethodsThis study included 53 individuals with SCD and 54 well-matched healthy controls (HC) from the Alzheimer's disease Neuroimaging Initiative (ADNI) database. Individual-level brain morphological networks were constructed by estimating the Jensen-Shannon distance-based similarity in the distribution of regional gray matter volume. Rich-club properties were then detected, followed by statistical comparison. ResultsThe characteristic rich-club organization of morphological networks (normalized rich-club coefficients > 1) was observed for both the SCD and HC groups under a range of thresholds. The SCD group showed a reduced normalized rich-club coefficient compared with the HC group. The SCD group exhibited the decreased strength and degree of rich-club connections than the HC group (strength: HC = 79.93, SCD = 74.37, p = 0.028; degree: HC = 85.28, SCD = 79.34, p = 0.027). Interestingly, the SCD group showed an increased strength of local connections than the HC group (strength: HC = 1982.16, SCD = 2003.38, p = 0.036). ConclusionRich-club organization disturbances of morphological networks in individuals with SCD reveal a distinct pattern between the rich-club and peripheral regions. This altered rich-club organization pattern provides novel insights into the underlying mechanism of SCD and could be used to investigate prevention strategies at the preclinical stage of AD.
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页数:8
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