Rich-club organization of the newborn human brain

被引:246
|
作者
Ball, Gareth [1 ]
Aljabar, Paul [1 ]
Zebari, Sally [1 ]
Tusor, Nora [1 ]
Arichi, Tomoki [1 ]
Merchant, Nazakat [1 ]
Robinson, Emma C. [2 ]
Ogundipe, Enitan [3 ]
Rueckert, Daniel [4 ]
Edwards, A. David [1 ]
Counsell, Serena J. [1 ]
机构
[1] Kings Coll London, St Thomas Hosp, Div Imaging Sci & Bioengn, Ctr Dev Brain,Kings Hlth Partners, London SE1 7EH, England
[2] Univ Oxford, Nuffield Dept Clin Neurosci, Funct Magnet Resonance Imaging Brain Grp, Oxford OX3 9DU, England
[3] Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Dept Paediat, London SW10 9NH, England
[4] Univ London Imperial Coll Sci Technol & Med, Dept Comp, Biomed Image Anal Grp, London SW7 2AZ, England
基金
英国工程与自然科学研究理事会; 英国医学研究理事会;
关键词
connectome; brain development; tractography; preterm birth; RESTING-STATE NETWORKS; FUNCTIONAL CONNECTIVITY; STRUCTURAL CONNECTIVITY; PRETERM BIRTH; WHITE-MATTER; FETAL; HUBS; ARCHITECTURE; SPECIFICITY; STABILITY;
D O I
10.1073/pnas.1324118111
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Combining diffusion magnetic resonance imaging and network analysis in the adult human brain has identified a set of highly connected cortical hubs that form a "rich club"-a high-cost, high-capacity backbone thought to enable efficient network communication. Rich-club architecture appears to be a persistent feature of the mature mammalian brain, but it is not known when this structure emerges during human development. In this longitudinal study we chart the emergence of structural organization in mid to late gestation. We demonstrate that a rich club of interconnected cortical hubs is already present by 30 wk gestation. Subsequently, until the time of normal birth, the principal development is a proliferation of connections between core hubs and the rest of the brain. We also consider the impact of environmental factors on early network development, and compare term-born neonates to preterm infants at term-equivalent age. Though rich-club organization remains intact following premature birth, we reveal significant disruptions in both in cortical-subcortical connectivity and short-distance corticocortical connections. Rich club organization is present well before the normal time of birth and may provide the fundamental structural architecture for the subsequent emergence of complex neurological functions. Premature exposure to the extrauterine environment is associated with altered network architecture and reduced network capacity, which may in part account for the high prevalence of cognitive problems in preterm infants.
引用
收藏
页码:7456 / 7461
页数:6
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