Towards population-specific pharmacogenomics in the era of next-generation sequencing

被引：7

作者：

Ji, Xiangjun ^{[1
,2
,3
]}

Ning, Baitang ^{[4
]}

Liu, Jinghua ^{[3
]}

Roberts, Ruth ^{[5
,6
]}

Lesko, Larry ^{[4
,7
]}

Tong, Weida ^{[4
]}

Liu, Zhichao ^{[4
]}

Shi, Tieliu ^{[1
,2
,4
,8
]}

机构：

[1] East China Normal Univ, Ctr Bioinformat & Computat Biol, Inst Biomed Sci, Shanghai 200241, Peoples R China

[2] East China Normal Univ, Sch Life Sci, Sch Stat, Shanghai 200241, Peoples R China

[3] Southern Med Univ, Sch Basic Med Sci, Guangdong Prov Key Lab Prote, Guangzhou, Peoples R China

[4] US FDA, Div Bioinformat & Biostat, Natl Ctr Toxicol Res, 3900 NCTR Rd, Jefferson, AR 72079 USA

[5] ApconiX, BioHub Alderley Pk, Alderley Edge SK10 4TG, England

[6] Univ Birmingham, Birmingham B15 2TT, W Midlands, England

[7] Univ Florida Lake Nona, Ctr Pharmacometr & Syst Pharmacol, Dept Pharmaceut, Orlando, FL USA

[8] Guangxi Med Univ, Natl Ctr Int Res Biol Targeting Diag & Therapy, Guangxi Key Lab Biol Targeting Diag & Therapy Res, Collaborat Innovat Ctr Targeting Tumor Diag & The, Nanning 530021, Guangxi, Peoples R China

来源：

DRUG DISCOVERY TODAY | 2021年 / 26卷 / 08期

基金：

国家高技术研究发展计划(863计划); 美国国家科学基金会;

关键词：

Pharmacogenomics; Next-generation sequencing; Population group; Biomarkers; US FDA; IMPACT; VALIDATION; GUIDELINES; DIVERSITY; GENOMICS; HEALTH;

D O I：

10.1016/j.drudis.2021.04.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pharmacogenomics (PGx) has essential roles in identifying optimal drug responders, optimizing dosage regimens and avoiding adverse events. Population-specific therapeutic interventions that tackle the genetic root causes of clinical outcomes are an important precision medicine strategy. In this perspective, we discuss next-generation sequencing genotyping and its significance for population specific PGx applications. We emphasize the potential of NGS for preemptive pharmacogenotyping, which is crucial to population-specific clinical studies and patient care. We also provide examples that use publicly available population-based genomics data for population-specific PGx studies. Last, we discuss the remaining challenges and regulatory efforts towards improvements in this field.

引用

页码：1776 / 1783

页数：8

共 50 条

[21] Next-generation sequencing and the era of personal Y genomes
Ayub, Qasim
Jostins, Luke
Xue, Yali
Turner, Daniel
Tyler-Smith, Chris
GENOME BIOLOGY, 2010, 11
[22] Next-Generation Sequencing in Oncology in the Era of Precision Medicine
Blumenthal, Gideon M.
Mansfield, Elizabeth
Pazdur, Richard
JAMA ONCOLOGY, 2016, 2 (01) : 13 - 14
[23] Principles of Genetic Counseling in the Era of Next-Generation Sequencing
Yang, Mina
Kim, Jong-Won
ANNALS OF LABORATORY MEDICINE, 2018, 38 (04) : 291 - 295
[24] Pathology provides clarity in the next-generation sequencing era
Ravenscroft, Gianina
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2015, 86 (05): : 479 - 480
[25] Clinical care models in the era of next-generation sequencing
Slavotinek, Anne
MOLECULAR GENETICS & GENOMIC MEDICINE, 2016, 4 (03): : 239 - 242
[26] Next-generation sequencing and the era of personal Y genomes
Qasim Ayub
Luke Jostins
Yali Xue
Daniel Turner
Chris Tyler-Smith
Genome Biology, 11 (Suppl 1)
[27] Genetics of movement disorders in the next-generation sequencing era
Olgiati, Simone
Quadri, Marialuisa
Bonifati, Vincenzo
MOVEMENT DISORDERS, 2016, 31 (04) : 458 - 470
[28] Variants of uncertain significance in the era of next-generation sequencing
Levkova, Mariya
Stoyanova, Milena
Benkova-Petrova, Miroslava
Georgieva, Miglena
Angelova, Lyudmila
JOURNAL OF THE AMERICAN ASSOCIATION OF NURSE PRACTITIONERS, 2022, 34 (08) : 1018 - 1021
[29] Molecular Modelling Hurdle in the Next-Generation Sequencing Era
Fernandez, Guerau
Yubero, Delia
Palau, Francesc
Armstrong, Judith
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (13)
[30] Treatment of myelodysplastic syndrome in the era of next-generation sequencing
Tobiasson, M.
Kittang, A. O.
JOURNAL OF INTERNAL MEDICINE, 2019, 286 (01) : 41 - 62

← 1 2 3 4 5 →