Synthesis of pyrazoline and isoxazole derivatives bearing chloroquinoline nucleus as potential antimicrobial agents

A series of pyrazolines 3a-j and isoxazoles 4a-k have been synthesized by the action of hydrazine hydrate and hydroxylamine hydrochloride respectively. on 1-aryl-3-(2'-chloro-7'-methylquinolin-3'-yl)-2-propen-1-ones 2 while the compounds 2 are prepared by the condensation of 2-chloro-7-methyl-quinoline-3-carboxaldehyde 1 with different aromatic ketones. All the compounds have been characterized on the basis of elemental analyses and spectral data. The compounds have been screened for their in vitro antifungal and antibacterial activities.