Synthesis of some 3-(5-chloro-1,3-diaryl-1H-pyrazol-4-yl)-1-arylprop-2-en-1-ones and 1,5-bis(5-chloro-1,3-diaryl-1H-pyrazol-4-yl)pent-1,4-diene-3-ones and their antimicrobial activity

New 3-(5-chloro-1,3-diaryl-1H-pyrazol-4-yl)-1-arylprop-2-en-1-ones (4a-n) and 1,5-bis(5-chloro-1,3-diaryl-1H-pyrazol-4-yl)pent-1,4-diene-3-ones (4o-r) have been synthesized by using aryl-5-chloro-4-formyl-1,2-pyrazoles (2a-d) as key intermediate, prepared by Vilsmeir-Haack reaction of pyrazolones. The compounds have been screened against multihost plant pathogenic fungi Macrophomina phaseolina and Sclerotium rolfsii and human pathogenic bacteria MTCCB 96 Staphylococcus aureus, MTCCB 1610 Escherichia coli, clinical isolate Citrobacter Sp. and Enterococcus faecium. Some compounds have shown promising activity against these microbes. Regression analysis has also been done for relationship between antifungal activity and concentration of compounds.