Microwave assisted synthesis of substituted 4-chloro-8-methyl-2-(1,3-diphenyl-1H-pyrazol-4-yl)-1,5-dioxa-2H-phenanthren-6-ones and their antimicrobial activity

Due to the potential antimicrobial activity of pyranochromenones and pyrazolines moieties, hybrid compounds containing both substituted 4-chloro-8-methyl-2-(1,3-diphenyl-1H-pyrazol-4-yl)-1,5-dioxa-2H-phenanthren-6-ones (4a-g), were synthesized from substituted (E)-1-(7-hydroxy-4-methyl-8-coumarinyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-propen-1-ones (3a-g) in good yield using the Vilsmeier reaction, by the microwave-assisted method. The structures of all the compounds were established based on their analytical and spectral data. All the synthesized compounds were tested in vitro for their antibacterial and antifungal activities. Some of the compounds showed very good activity compared to standard drugs against all the tested pathogenic bacteria and fungi.