Bone Ingrowth Around an Uncemented Femoral Implant Using Mechanoregulatory Algorithm: A Multiscale Finite Element Analysis

The primary fixation and long-term stability of a cementless femoral implant depend on bone ingrowth within the porous coating. Although attempts were made to quantify the peri-implant bone ingrowth using the finite element (FE) analysis and mechanoregulatory principles, the tissue differentiation patterns on a porous-coated hip stem have scarcely been investigated. The objective of this study is to predict the spatial distribution of evolutionary bone ingrowth around an uncemented hip stem, using a three-dimensional (3D) multiscale mechanobiology-based numerical framework. Multiple load cases representing a variety of daily living activities, including walking, stair climbing, sitting down, and standing up from a chair, were used as applied loading conditions. The study accounted for the local variations in host bone material properties and implant-bone relative displacements of the macroscale implanted FE model, in order to predict bone ingrowth in microscale representative volume elements (RVEs) of 12 interfacial regions. In majority RVEs, 20-70% bone tissue (immature and mature) was predicted after 2 months, contributing toward a progressive increase in average Young's modulus (1200-3000 MPa) of the interbead tissue layer. Higher bone ingrowth (mostly greater than 60%) was predicted in the anterolateral regions of the implant, as compared to the posteromedial side (20-50%). New bone tissue was formed deeper inside the interbead spacing, adhering to the implant surface. The study helps to gain an insight into the degree of osseointegration of a porous-coated femoral implant.