Gold-catalyzed cyclization in the synthesis of antimitotic 2,3-dihydrobenzo[b]oxepine derivatives of colchicine

被引：3
|
作者：
Bukhvalova, S. Yu. [1 ,2 ]
Maleev, A. A. [2 ]
Gracheva, Yu. A. [2 ]
Voitovich, Yu. V. [2 ]
Ignatov, S. K. [2 ]
Svirshchevskaya, E. V. [3 ]
Fedorov, A. Yu. [2 ]
机构：
[1] Russian Acad Sci, GA Razuvaev Inst Organometall Chem, 49 Ul Tropinina, Nizhnii Novgorod 603137, Russia
[2] NI Lobachevsky State Univ Nizhny Novgorod, 23 Prosp Gagarina, Nizhnii Novgorod 603950, Russia
[3] Russian Acad Sci, MM Shemyakin Yu A Ovchinnikov Inst Bioorgan Chem, 16-10 Ul Miklukho Maklaya, Moscow 117997, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2019年 / 68卷 / 12期
基金：
俄罗斯科学基金会;
关键词：
antitumor agents; colchicine; tubulin; benzo [b] oxepines; gold-catalyzed cyclization; BIOLOGICAL EVALUATION; PTERULINIC ACID; TUBULIN; COMPLEX; TRIAL; ANTICANCER; INHIBITORS; CHEMISTRY; PTERULONE; RADULANIN;
D O I：
10.1007/s11172-019-2689-7
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New allocolchicine derivatives bearing 2,3-dihydrobenzo[b]oxepine moiety were synthesized via gold-catalyzed cyclization as a key synthetic step. The obtained 2,3-dihydrobenzo[b]oxepine-containing allocolchicinoids possess cytotoxic activity against HEK293, PANC-1, COL0357, HeLa, and Colon26 cancer cell lines at low micromolar range of concentrations.
引用
收藏
页码：2205 / 2215
页数：11
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