A New Megastigmane Alkaloid from Pachysandra terminalis with Antitumor Metastasis Effect

被引：9
|
作者：
Jin, Mei-Na [1 ]
Ma, Sheng-Nan [1 ,2 ]
Zhai, Hui-Yuan [1 ,3 ]
Nan-Qin [4 ]
Duan, Hong-Quan [1 ,4 ]
Kong, De-Xin [1 ,4 ]
机构：
[1] Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China
[2] Tianjin 4th Ctr Hosp, Tianjin 300140, Peoples R China
[3] Nanjing Integrated Tradit Chinese & Western Med H, Nanjing 210014, Peoples R China
[4] Tianjin Med Univ, Res Ctr Basic Med Sci, Tianjin 300070, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2015年 / 51卷 / 02期
基金：
中国国家自然科学基金;
关键词：
megastigmane alkaloid; antitumor metastasis; p-PKC zeta; p-integrin beta 1; anti-angiogenic activity; PROTEIN-KINASE-C; TOBACCO CHEMISTRY; CANCER INVASION; CELL POLARITY; PKC-ZETA; ACTIVATION;
D O I：
10.1007/s10600-015-1267-y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
9-(N,N-Dimethyl)-4,7-megastigmedien-3-one (1) was isolated from Pachysandra terminalis and identified by 1D and 2D NMR spectroscopic and mass spectrometric methods. Compound 1 revealed significant anti-metastasis effect on cancer cell migration and invasion through suppressing the expressions of p-PKC zeta and p-integrin beta 1 in human breast cancer cells, and also showed anti-angiogenic activity on human umbilical vein endothelial cells.
引用
收藏
页码：311 / 315
页数：5
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