ORAL LORAZEPAM PREVENTS SEIZURE DURING HIGH-DOSE BUSULFAN IN CHILDREN UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION: A Prospective Study

被引：7
|
作者：
Hamidieh, Amir Ali [2 ]
Hamedani, Ravak [1 ]
Hadjibabaie, Molouk [1 ]
Amini, Mohsen [3 ]
Sadrai, Sima [4 ]
Ghavamzadeh, Ardeshir [2 ]
机构：
[1] Univ Tehran Med Sci, Dept Clin Pharm, Fac Pharm, Tehran, Iran
[2] Univ Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran
[3] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran, Iran
[4] Univ Tehran Med Sci, Dept Pharmacokinet, Fac Pharm, Tehran, Iran
来源：
PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2010年 / 27卷 / 07期
关键词：
anticonvulsants; busulfan; hematopoietic stem cell transplantation; lorazepam; MARROW TRANSPLANTATION; ACUTE-LEUKEMIA; CYCLOPHOSPHAMIDE; PROPHYLAXIS; PHARMACOKINETICS;
D O I：
10.3109/08880018.2010.496895
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
High-dose Busulfan in combination chemotherapy has been used commonly for hematopoietic stem cell transplantation. It crosses the blood-brain barrier and could cause seizure. Benzodiazepines have been used as anticonvulsant prophylaxis. This is a prospective study using oral lorazepam together with busulfan-based conditioning regimen in 30 children undergoing hematopoietic stem cell transplantation. The dose of lorazepam used ranged from 0.017 to 0.039 mg/kg (median = 0.026 mg/kg) per dose. None of the patients developed seizure while receiving oral lorazepam or within 72 hours of the last dose of Busulfan. Oral lorazepam was tolerated by the patients, but all patients needed dose reduction due to some adverse effects. In the authors' experience, oral lorazepam is a useful anticonvulsant prophylaxis for children receiving high-dose busulfan.
引用
收藏
页码：529 / 533
页数：5
相关论文
共 50 条
  • [31] Phase II study of high-dose thiotepa and hematopoietic stem cell transplantation in children with solid tumors
    Lucidarme, N
    Valteau-Couanet, D
    Oberlin, O
    Couanet, D
    Kalifa, C
    Beaujean, F
    Lapierre, V
    Hartmann, O
    BONE MARROW TRANSPLANTATION, 1998, 22 (06) : 535 - 540
  • [32] Phase II study of high-dose thiotepa and hematopoietic stem cell transplantation in children with solid tumors
    N Lucidarme
    D Valteau-Couanet
    O Oberlin
    D Couanet
    C Kalifa
    F Beaujean
    V Lapierre
    O Hartmann
    Bone Marrow Transplantation, 1998, 22 : 535 - 540
  • [33] Phenytoin as seizure prophylaxis in hematopoietic stem cell transplantation with busulfan conditioning
    Germeraad, R. S.
    Demandt, A. M. P.
    Rouhl, R. P. W.
    FRONTIERS IN NEUROLOGY, 2022, 13
  • [34] Electroencephalogram abnormality and high-dose busulfan in conditioning regimens for stem cell transplantation
    R Kobayashi
    N Watanabe
    A Iguchi
    Y Cho
    M Yoshida
    H Arioka
    H Naito
    T Shikano
    Y Ishikawa
    Bone Marrow Transplantation, 1998, 21 : 217 - 220
  • [35] Electroencephalogram abnormality and high-dose busulfan in conditioning regimens for stem cell transplantation
    Kobayashi, R
    Watanabe, N
    Iguchi, A
    Cho, Y
    Yoshida, M
    Arioka, H
    Naito, H
    Shikano, T
    Ishikawa, Y
    BONE MARROW TRANSPLANTATION, 1998, 21 (03) : 217 - 220
  • [36] High-dose weekly AmBisome antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: A pharmacokinetic study
    Mehta, P
    Vinks, A
    Filipovich, A
    Vaughn, G
    Fearing, D
    Sper, C
    Davies, S
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2006, 12 (02) : 235 - 240
  • [37] Therapeutic drug monitoring of intravenous busulfan in Thai children undergoing hematopoietic stem cell transplantation: A pilot study
    Jansing, Thaksin
    Sanpakit, Kleebsabai
    Tharnpanich, Trai
    Jiranantakan, Thanjira
    Niphandwongkorn, Vachira
    Chindavijak, Busba
    Suansanae, Thanarat
    PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2021, 38 (04) : 346 - 357
  • [38] Safety, Efficacy, and Pharmacokinetics of Intravenous Busulfan in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
    Wall, Donna A.
    Chan, Ka Wah
    Nieder, Michael L.
    Hayashi, Robert J.
    Yeager, Andrew M.
    Kadota, Richard
    Przepiorka, Donna
    Mezzi, Khaled
    Kletzel, Morris
    PEDIATRIC BLOOD & CANCER, 2010, 54 (02) : 291 - 298
  • [39] Left ventricular dysfunction in patients undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation
    Potemkina, N. A.
    Zeynalova, P. A.
    Petrova, G. D.
    Novikova, A. I.
    Andreeva, O. V.
    Kuli-Zade, Z. A.
    Fashafsha, Zaki Z. A.
    Chomakhidze, P. Sh.
    Poltavskaya, M. G.
    KARDIOLOGIYA, 2023, 63 (10) : 91 - 94
  • [40] High-Dose Melphalan Versus Busulfan, Cyclophosphamide As Conditioning Regimens for Hematopoietic Stem Cell Transplantation in Patients with Multiple Myeloma
    Styler, Michael
    Crilley, Pamela Ann
    Jain, Maneesh
    Ward, Kristine
    Topolsky, David
    Cho, David
    Kim, Marc
    BLOOD, 2015, 126 (23)
12345