Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease

被引：10
|
作者：
Kourtidou, Christodoula [1 ]
Stangou, Maria [2 ]
Marinaki, Smaragdi [3 ]
Tziomalos, Konstantinos [1 ]
机构：
[1] Aristotle Univ Thessaloniki, AHEPA Hosp, Med Sch, Propedeut Dept Internal Med 1, Thessaloniki 54636, Greece
[2] Aristotle Univ Thessaloniki, Hippokration Hosp, Med Sch, Dept Nephrol, Thessaloniki 54642, Greece
[3] Natl & Kapodistrian Univ Athens, Laiko Hosp, Med Sch, Dept Nephrol & Renal Transplantat, Athens 11527, Greece
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 20期
关键词：
diabetes mellitus; diabetic kidney disease; cardiovascular risk; neutrophil gelatinase-associated lipocalin; kidney injury molecule-1; lipoxygenases; copeptin; matrix metalloproteinases; fibroblast growth factor-23; klotho; cubilin; GELATINASE-ASSOCIATED LIPOCALIN; DECLINING GLOMERULAR-FILTRATION; TO-CREATININE RATIO; ALL-CAUSE MORTALITY; ARGININE-VASOPRESSIN; PLASMA VASOPRESSIN; GENE POLYMORPHISM; SURROGATE MARKER; SOLUBLE KLOTHO; RENAL-DISEASE;
D O I：
10.3390/ijms222011196
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Patients with diabetic kidney disease (DKD) are at very high risk for cardiovascular events. Only part of this increased risk can be attributed to the presence of diabetes mellitus (DM) and to other DM-related comorbidities, including hypertension and obesity. The identification of novel risk factors that underpin the association between DKD and cardiovascular disease (CVD) is essential for risk stratification, for individualization of treatment and for identification of novel treatment targets.In the present review, we summarize the current knowledge regarding the role of emerging cardiovascular risk markers in patients with DKD. Among these biomarkers, fibroblast growth factor-23 and copeptin were studied more extensively and consistently predicted cardiovascular events in this population. Therefore, it might be useful to incorporate them in risk stratification strategies in patients with DKD to identify those who would possibly benefit from more aggressive management of cardiovascular risk factors.
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收藏
页数：11
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