A NON-EQUILIBRIUM THERMODYNAMIC APPROACH TO SYMMETRY BREAKING IN CANCER

被引：2

作者：

Lucia, Umberto ^{[1
]}

Grisolia, Giulia ^{[1
]}

Deisboeck, Thomas S. ^{[2
,3
]}

机构：

[1] Politecn Torino, Dipartimento Energia Galileo Ferraris, Corso Duca Abruzzi 24, I-10129 Turin, Italy

[2] Harvard MIT Martinos Ctr Biomed Imaging, Dept Radiol, Charlestown, MA 02129 USA

[3] Harvard Med Sch, Charlestown, MA 02129 USA

来源：

ATTI ACCADEMIA PELORITANA DEI PERICOLANTI-CLASSE DI SCIENZE FISICHE MATEMATICHE E NATURALI | 2021年 / 99卷 / 01期

关键词：

FRACTALS;

D O I：

10.1478/AAPP.991A1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This paper develops a non-equilibrium thermodynamics approach to oncogenesis, with a particular focus on 'symmetry breaking'. The Onsager phenomenological coefficients are introduced to show the biophysical and thermophysical properties of cellular systems with differences between normal and cancerous cells. Seebeck- and Peltier-like effects are introduced to simplify the description of heat exchange and ion fluxes, in an effort to characterize the distinct role of the cellular electric membrane potential. Our results indicate that oncogenesis leads to changes in: (i) the thermophysical properties of the cell cytoplasm, caused by differences in density and heat capacity, (ii) the interactions with the micro-environment, (iii) geometrical characteristics, both in fractal dimensions and in shape symmetry, and (iv) the constitutive properties of membrane fluxes. This presents a unifying biophysics concept for such diverse characteristics, and it may yield new diagnostic and therapeutic opportunities.

引用

页数：12

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