Rho-associated kinase in the gustatory cortex is involved in conditioned taste aversion memory formation but not in memory retrieval or relearning

被引：3

作者：

Sweetat, Sahar ^{[1
]}

Rosenblum, Kobi ^{[1
,2
]}

Lamprecht, Raphael ^{[1
,2
,3
]}

机构：

[1] Univ Haifa, Fac Nat Sci, Dept Neurobiol & Ethol, IL-31905 Haifa, Israel

[2] Univ Haifa, Ctr Gene Manipulat Brain, IL-31905 Haifa, Israel

[3] Univ Haifa, Ctr Brain & Behav, IL-31905 Haifa, Israel

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2012年 / 97卷 / 01期

基金：

以色列科学基金会;

关键词：

Insular cortex; Conditioned taste aversion; Long-term memory; Rho-associated kinase; INSULAR CORTEX; PROTEIN-KINASE; P190; RHOGAP; IN-VIVO; AMYGDALA; ROCK; NEURONS; PATHWAY; GROWTH; DISSOCIATIONS;

D O I：

10.1016/j.nlm.2011.08.007

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Rho-associated kinase (ROCK) is intimately involved in cortical neuronal morphogenesis. The present study explores the roles of ROCK in conditioned taste aversion (CTA) memory formation in gustatory cortex (GC) in adult rat. Microinjection of the ROCK inhibitor Y-27632 into the GC 30 min before CTA training or 10 min after the conditioned stimulus (CS) impaired long-term CTA memory (LTM) formation. ROCK inhibitor had no effect on taste aversion when injected before the first LTM test day and did not alter taste aversion on subsequent test days. Microinjection of ROCK inhibitor into GC 30 min before preexposure to the taste CS had no effect on latent inhibition of CTA learning suggesting that ROCK is involved in CS-US association rather than taste learning per se. Cumulatively, these results show that ROCK is needed for normal CTA memory formation but not retrieval, relearning or incidental taste learning. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1 / 6

页数：6