Synthesis, characterization and antileishmanial activity of copper(II) and zinc(II) complexes with diamine ligands

被引：7
|
作者：
Conde, Camila A. S. R. [1 ]
De Almeida, Mauro, V [2 ]
Da Silva, Gabrielle dos Santos [3 ]
Pires de Abreu Sodre, Milena Barenco [3 ]
Fernandes Rodrigues, Juliany Cola [3 ]
Navarro, Maribel [1 ]
机构：
[1] Univ Fed Juiz de Fora, Inst Ciencias Exatas, Dept Quim, Lab Quim Bioinorgan & Catalises LaQB, Juiz De Fora, MG, Brazil
[2] Univ Fed Juiz de Fora, Inst Ciencias Exatas, Dept Quim, Juiz De Fora, MG, Brazil
[3] Nucleo Multidisciplinar Pesquisa Biol NUMPEX Bio, Campus UFRJ Duque Caxias Prof Geraldo Cidade, Duque De Caxias, RJ, Brazil
来源：
TRANSITION METAL CHEMISTRY | 2022年 / 47卷 / 4-5期
关键词：
VISCERAL LEISHMANIASIS; ORGANORUTHENIUM COMPLEXES; IN-VITRO; AMAZONENSIS; BINDING; CU(II); BRAZIL;
D O I：
10.1007/s11243-022-00495-7
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new set of copper- and zinc-diamine (N-alkylated (L1) and N,N'-dialkylated (L2)) complexes, [Cu(L1)(2)(NO3)(2)] (1), [Cu(L1)(2)(Cl)(2)].5H(2)O (2), [Cu(L2)(2)(NO3)(2)] (3), [Cu(L2)(2)(Cl)(2)] (4), [Zn(L1)(2)(C2H3O2)(2)] (5), [Zn(L1)(2)(Cl)(2)] (6), [Zn(L2)(2)(C2H3O2)(2)] (7), [Zn(L2)(2)(Cl)(2)] (8) were prepared by a reaction of the N-alkylated (L1) and N,N'-dialkylated (L2) with their respective copper and zinc salts under mild conditions. The metal complexes were fully characterized by physicochemical and spectroscopic methods. All new metal compounds exhibited significant biological activity against Leishmania amazonensis promastigotes when compared to the free ligands (L1 and L2).
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收藏
页码：147 / 156
页数：10
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