Regioselective transition metal-free acylation of coumarins via cross-dehydrogenative coupling reaction of coumarins and aldehydes

被引：16
|
作者：
Adib, Mehdi [1 ]
Rajai-Daryasarei, Saideh [1 ]
Pashazadeh, Rahim [1 ]
Tajik, Mahnaz [1 ]
Mirzaei, Peiman [2 ]
机构：
[1] Univ Tehran, Coll Sci, Sch Chem, POB 14155-6455, Tehran, Iran
[2] Shahid Beheshti Univ, Dept Chem, Tehran, Iran
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 33期
关键词：
Cross-dehydrogenative coupling; Transition metal-free; Coumarins; Aldehydes; 3-Acylcoumarins; Acylation; POTENTIAL ANTIVIRAL AGENTS; BOND FORMATION; ACYCLIC DERIVATIVES; N-HETEROCYCLES; INHIBITORS; ALKYNOATES; ETHERS; GLYCOSIDOPYRROLES; POLYFLUOROARENE; ANTIBACTERIAL;
D O I：
10.1016/j.tetlet.2016.06.061
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A transition metal-free cross-dehydrogenative coupling reaction is described for the preparation of 3-acylcoumarins. Heating a mixture of a coumarin, an aldehyde, and the K2S2O8/Aliquat 336 system in chlorobenzene at 100 degrees C for 8 h regioselectively afforded the corresponding 3-acylcoumarin derivatives in good to excellent yields. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3701 / 3705
页数：5
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