Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer

被引：38
|
作者：
Bao, Yonghua [1 ]
Guo, Yongchen [1 ]
Zhang, Chenglan [2 ]
Fan, Fenghua [2 ]
Yang, Wancai [1 ,3 ]
机构：
[1] Jining Med Univ, Inst Precis Med, Jining 272067, Peoples R China
[2] Hlth Profess Coll Heilongjiang Prov, Dept Nursing, Beian 164000, Peoples R China
[3] Univ Illinois, Dept Pathol, Chicago, IL 60612 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 10期
关键词：
sphingosine kinase 1; sphingosine-1-phosphate; colorectal cancer; CHRONIC INTESTINAL INFLAMMATION; FUNCTIONAL-CHARACTERIZATION; HUMAN COLON; MOLECULAR-CLONING; CELL-MIGRATION; LIVER-CANCER; EXPRESSION; LOCALIZATION; COLITIS; PROTEIN;
D O I：
10.3390/ijms18102109
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sphingosine kinase 1 (Sphk1) is a highly conserved lipid kinase that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P). Growing studies have demonstrated that Sphk1 is overexpressed in various types of solid cancers and can be induced by growth factors, cytokines, and carcinogens, leading to the increase of S1P production. Subsequently, the increased Sphk1/S1P facilitates cancer cell proliferation, mobility, angiogenesis, invasion, and metastasis. Therefore, Sphk1/S1P signaling plays oncogenic roles. This review summarizes the features of Sphk1/S1P signaling and their functions in colorectal cancer cell growth, tumorigenesis, and metastasis, as well as the possible underlying mechanisms.
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页数：11
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