Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

被引：0

作者：

Garboczi, David N. ^{[1
,2
]}

Ghosh, Partho ^{[1
,2
]}

Utz, Ursula ^{[3
]}

Fan, Qing R. ^{[1
,2
]}

Biddison, William E. ^{[4
]}

Wiley, Don C. ^{[1
,2
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA

[3] Inst Rech Clin Montreal, Immunol Lab, Montreal, PQ H2W 1R7, Canada

[4] NINDS, Mol Immunol Sect, Neuroimmunol Branch, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 185卷 / 11期

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histo-compatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.

引用

页码：134 / 141

页数：8

共 50 条

[1] Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
Garboczi, DN
Ghosh, P
Utz, U
Fan, QR
Biddison, WE
Wiley, DC
NATURE, 1996, 384 (6605) : 134 - 141
[2] Structural, biochemical, and biophysical studies of HLA-A2/altered peptide ligands binding to viral-peptide-specific human T-cell receptors
Baker, BM
Ding, YH
Garboczi, DN
Biddison, WE
Wiley, DC
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1999, 64 : 235 - 241
[3] Crystal structure of the complex between human CD8αα and HLA-A2
George F. Gao
José Tormo
Ulrich C. Gerth
Jessica R. Wyer
Andrew J. McMichael
David I. Stuart
John I. Bell
E. Yvonne Jones
Bent K. Jakobsen
Nature, 1997, 387 : 630 - 634
[4] VIRAL PEPTIDES THAT INTERACT WITH HLA-A2 INHIBIT CYTO-TOXIC T-CELL ACTIVITY
ROBBINS, PA
MCMICHAEL, AJ
HUMAN IMMUNOLOGY, 1988, 23 (02) : 139 - 139
[5] In vivo selection of T-cell receptor junctional region sequences by HLA-A2 human T-cell lymphotropic virus type 1 Tax11-29 peptide complexes
Saito, M
Taylor, GP
Saito, A
Furukawa, Y
Usuku, K
Weber, JN
Osame, M
Bangham, CRM
JOURNAL OF VIROLOGY, 2001, 75 (02) : 1065 - 1071
[6] ROLES OF THE 6 PEPTIDE-BINDING POCKETS OF THE HLA-A2 MOLECULE IN ALLORECOGNITION BY HUMAN CYTOTOXIC T-CELL CLONES
MATSUI, M
HIOE, CE
FRELINGER, JA
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) : 674 - 678
[7] Assembly and crystallization of the complex between the human T cell coreceptor CD8α homodimer and HLA-A2
Gao, GF
Gerth, UC
Wyer, JR
Willcox, BE
O'Callaghan, CA
Zhang, ZH
Jones, EY
Bell, JI
Jakobsen, BK
PROTEIN SCIENCE, 1998, 7 (05) : 1245 - 1249
[8] EXTENSIVE CONSERVATION OF ALPHA-CHAIN AND BETA-CHAIN OF THE HUMAN T-CELL ANTIGEN RECEPTOR RECOGNIZING HLA-A2 AND INFLUENZA-A MATRIX PEPTIDE
MOSS, PAH
MOOTS, RJ
ROSENBERG, WMC
ROWLANDJONES, SJ
BODMER, HC
MCMICHAEL, AJ
BELL, JI
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (20) : 8987 - 8990
[9] Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor
Willcox, BE
Thomas, LM
Bjorkman, PJ
NATURE IMMUNOLOGY, 2003, 4 (09) : 913 - 919
[10] Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor
Benjamin E Willcox
Leonard M Thomas
Pamela J Bjorkman
Nature Immunology, 2003, 4 : 913 - 919

← 1 2 3 4 5 →