Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

被引：0

作者：

Garboczi, David N. ^{[1
,2
]}

Ghosh, Partho ^{[1
,2
]}

Utz, Ursula ^{[3
]}

Fan, Qing R. ^{[1
,2
]}

Biddison, William E. ^{[4
]}

Wiley, Don C. ^{[1
,2
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA

[3] Inst Rech Clin Montreal, Immunol Lab, Montreal, PQ H2W 1R7, Canada

[4] NINDS, Mol Immunol Sect, Neuroimmunol Branch, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 185卷 / 11期

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histo-compatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.

引用

页码：134 / 141

页数：8

共 50 条

[21] STRUCTURE OF HUMAN T-CELL RECEPTORS SPECIFIC FOR AN IMMUNODOMINANT MYELIN BASIC-PROTEIN PEPTIDE - POSITIONING OF T-CELL RECEPTORS ON HLA-DR2 PEPTIDE COMPLEXES
WUCHERPFENNIG, KW
HAFLER, DA
STROMINGER, JL
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (19) : 8896 - 8900
[22] EXPRESSION OF HLA-A2 ANTIGEN IN HUMAN-MELANOMA CELL-LINES AND ITS ROLE IN T-CELL RECOGNITION
PANDOLFI, F
BOYLE, LA
TRENTIN, L
KURNICK, JT
ISSELBACHER, KJ
GATTONICELLI, S
CANCER RESEARCH, 1991, 51 (12) : 3164 - 3170
[23] A trimolecular complex: production, crystallization and preliminary x-ray analysis of a human alpha/beta T cell receptor, a peptide, and the class I MHC molecule HLA-A2
Garboczi, DN
Ghosh, P
Utz, U
Biddison, WE
Wiley, DC
HLA - GENETIC DIVERSITY OF HLA FUNCTIONAL AND MEDICAL IMPLICATION, PROCEEDINGS OF THE TWELFTH INTERNATIONAL HISTOCOMPATIBILITY WORKSHOP AND CONFERENCE (12TH IHWC), VOL II: CONFERENCE, 1997, : 13 - 17
[24] Structure of a human γδ T-cell antigen receptor
Timothy J. Allison
Christine C. Winter
Jean-Jacques Fournié
Marc Bonneville
David N. Garboczi
Nature, 2001, 411 : 820 - 824
[25] Structure of a human γδ T-cell antigen receptor
Allison, TJ
Winter, CC
Fournié, JJ
Bonneville, M
Garboczi, DN
NATURE, 2001, 411 (6839) : 820 - 824
[26] THE HUMAN T-CELL RECEPTOR - STRUCTURE AND FUNCTION
ACUTO, O
REINHERZ, EL
NEW ENGLAND JOURNAL OF MEDICINE, 1985, 312 (17): : 1100 - 1111
[27] HLA GENES INFLUENCE THE HUMAN T-CELL RECEPTOR REPERTOIRE
GULWANIAKOLKAR, B
GREGERSEN, PK
AKOLKAR, P
MANJI, R
JANSON, CH
POSNETT, D
SILVER, J
FASEB JOURNAL, 1991, 5 (06): : A1700 - A1700
[28] T-CELL RECEPTOR USAGE AND EPITOPE MAPPING OF HLA-A2 RESTRICTED, MELANOMA REACTIVE CTL CLONES AND OLIGOCLONAL LINES
COLE, DJ
WEIL, DP
SHILYANSKY, J
CUSTER, M
KAWAKAMI, Y
YANNELLI, J
ROSENBERG, SA
NISHIMURA, MI
FASEB JOURNAL, 1995, 9 (04): : A801 - A801
[29] COMPARISON BETWEEN 2 PEPTIDE EPITOPES PRESENTED TO CYTO-TOXIC LYMPHOCYTES-T BY HLA-A2 - EVIDENCE FOR DISCRETE LOCATIONS WITHIN HLA-A2
ROBBINS, PA
LETTICE, LA
ROTA, P
SANTOSAGUADO, J
ROTHBARD, J
MCMICHAEL, AJ
STROMINGER, JL
JOURNAL OF IMMUNOLOGY, 1989, 143 (12): : 4098 - 4103
[30] Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids
Ding, YH
Smith, KJ
Garboczi, DN
Utz, U
Biddison, WE
Wiley, DC
IMMUNITY, 1998, 8 (04) : 403 - 411

← 1 2 3 4 5 →