Recent advances in therapeutic strategies for triple-negative breast cancer

被引：261
|
作者：
Li, Yun [1 ]
Zhang, Huajun [1 ]
Merkher, Yulia [2 ]
Chen, Lin [1 ]
Liu, Na [3 ]
Leonov, Sergey [2 ,4 ]
Chen, Yongheng [1 ,5 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Oncol, NHC Key Lab Canc Prote,Lab Struct Biol, Changsha 410008, Hunan, Peoples R China
[2] Moscow Inst Phys & Technol, Sch Biol & Med Phys, Dolgoprudnyi 141700, Moscow Region, Russia
[3] Cent South Univ, Xiangya Hosp, Dept Endocrinol, Changsha 410008, Hunan, Peoples R China
[4] Russian Acad Sci, Inst Cell Biophys, Pushchino 142290, Russia
[5] Cent South Univ, Natl Clin Res Ctr Geriatr Disorders, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China
来源：
JOURNAL OF HEMATOLOGY & ONCOLOGY | 2022年 / 15卷 / 01期
基金：
俄罗斯科学基金会; 中国国家自然科学基金;
关键词：
Triple-negative breast cancer; Targeted therapy; Immunotherapy; Combination therapy; PATHOLOGICAL COMPLETE RESPONSE; EPITHELIAL-MESENCHYMAL TRANSITION; CONJUGATE GLEMBATUMUMAB VEDOTIN; TUMOR-INFILTRATING LYMPHOCYTES; PHASE-II; TGF-BETA; NEOADJUVANT CHEMOTHERAPY; DOUBLE-BLIND; OPEN-LABEL; RESIDUAL DISEASE;
D O I：
10.1186/s13045-022-01341-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC) with a poor prognosis. Current treatment options are limited to surgery, adjuvant chemotherapy and radiotherapy; however, a proportion of patients have missed the surgical window at the time of diagnosis. TNBC is a highly heterogeneous cancer with specific mutations and aberrant activation of signaling pathways. Hence, targeted therapies, such as those targeting DNA repair pathways, androgen receptor signaling pathways, and kinases, represent promising treatment options against TNBC. In addition, immunotherapy has also been demonstrated to improve overall survival and response in TNBC. In this review, we summarize recent key advances in therapeutic strategies based on molecular subtypes in TNBC.
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页数：30
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