A one-pot process for the enantioselective synthesis of amines via reductive amination under transfer hydrogenation conditions

被引：135

作者：

Williams, GD

Pike, RA

Wade, CE

Wills, M ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] GlaxoSmithKline Pharmaceut Ltd, Proc Chem Dept, Stevenage SG1 2BX, Herts, England

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 22期

关键词：

D O I：

10.1021/ol035746r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclic amines may be prepared via a sequence of deprotection followed by intramolecular reductive amination of t-Boc-protected amino ketones under asymmetric transfer hydrogenation conditions. In cases where the corresponding imine reaction proceeds with high enantioselectivity, this is reflected in the one-step process.

引用

页码：4227 / 4230

页数：4

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