Pharmacological characterization of CHI25243, a novel potent inhaled inhibitor of neutrophil elastase

被引:0
|
作者
Miglietta, Daniela
Carnini, Chiara
Puviani, Veronica
Finch, Harry
Fox, Craig
Fitzgerald, Mary
Patacchini, Riccardo
Civelli, Maurizio
Villetti, Gino
机构
关键词
Anti-inflammatory; Inflammation; Infections;
D O I
10.1183/13993003.congress-2016.OA4539
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
OA4539
引用
收藏
页数:2
相关论文
共 50 条
  • [21] ONO-5046, A NOVEL INHIBITOR OF HUMAN NEUTROPHIL ELASTASE
    KAWABATA, K
    SUZUKI, M
    SUGITANI, M
    IMAKI, K
    TODA, M
    MIYAMOTO, T
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 177 (02) : 814 - 820
  • [22] Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors
    Crocetti, Letizia
    Giovannoni, Maria Paola
    Cantini, Niccolo
    Guerrini, Gabriella
    Vergelli, Claudia
    Schepetkin, Igor A.
    Khlebnikov, Andrei I.
    Quinn, Mark T.
    FRONTIERS IN CHEMISTRY, 2020, 8
  • [23] ONO-6818, a novel, potent neutrophil elastase inhibitor, reduces inflammatory mediators during simulated extracorporeal circulation
    Yoshimura, Y
    Hiramatsu, Y
    Sato, Y
    Homma, S
    Enomoto, Y
    Jikuya, T
    Sakakibara, Y
    ANNALS OF THORACIC SURGERY, 2003, 76 (04): : 1234 - 1239
  • [24] Synthesis and Pharmacological Evaluation of Indole Derivatives as Deaza Analogues of Potent Human Neutrophil Elastase Inhibitors
    Crocetti, Letizia
    Schepetkin, Igor A.
    Ciciani, Giovanna
    Giovannoni, Maria Paola
    Guerrini, Gabriella
    Iacovone, Antonella
    Khlebnikov, Andrei I.
    Kirpotina, Liliya N.
    Quinn, Mark T.
    Vergelli, Claudia
    DRUG DEVELOPMENT RESEARCH, 2016, 77 (06) : 285 - 299
  • [25] In vitro and in vivo characterisation of the novel neutrophil elastase inhibitor BI 1323495
    Kreideweiss, Stefan
    Schuler-Metz, Annette
    Gnamm, Christian
    Peters, Stefan
    Oost, Thorsten
    EUROPEAN RESPIRATORY JOURNAL, 2020, 56
  • [26] Hydroxyhibiscone A, a Novel Human Neutrophil Elastase Inhibitor from Hibiscus syriacus
    Ryoo, In-Ja
    Yun, Bong-Sik
    Lee, In-Kyoung
    Kim, Young-Hee
    Lee, Ik-Soo
    Ahn, Jong-Seok
    Bae, KiHwan
    Yoo, Ick-Dong
    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2010, 20 (08) : 1189 - 1191
  • [27] Novel peptidyl trifluoromethyl ketone inhibitor of human neutrophil elastase.
    Omodani, T
    Inoue, Y
    Shiratake, R
    Honda, S
    Sato, F
    Imano, K
    Okazaki, H
    Kubo, T
    Kuromiya, A
    Takemura, T
    Komiya, M
    Kyoya, Y
    Kurono, M
    Tuji, J
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U43 - U43
  • [28] A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats
    Kuraki, T
    Ishibashi, M
    Takayama, M
    Shiraishi, M
    Yoshida, M
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 166 (04) : 496 - 500
  • [29] Characterization of a novel elastase inhibitor from a fan coral
    Comptes Rendus L'Academie Sci Ser III Sci Vie, 5 (365):
  • [30] ONO-5046 is a potent inhibitor of neutrophil elastase in human pleural effusion after lobectomy
    Sakuma, T
    Takahashi, K
    Ohya, N
    Usuda, K
    Handa, M
    Abe, T
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 353 (2-3) : 273 - 279