Preparation, characterization and anticoagulant activity of guar gum sulphate

被引：4
|
作者：
Li, Q [1 ]
He, DB
Chen, W
Ni, LH
机构：
[1] Xiamen Univ, Environm Sci Res Ctr, Xiamen 361005, Peoples R China
[2] Wuhan Univ, Dept Environm Sci, Wuhan 430072, Hubei, Peoples R China
来源：
JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY | 2005年 / A42卷 / 08期
基金：
中国国家自然科学基金;
关键词：
guar gum; sulphonation; anticoagulant activity;
D O I：
10.1081/MA-200065936
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Guar gum was chemically modified by sulphonation using chlorosulphonic acid (ClSO3H) as a reagent. Effects of molar ratio Of ClSO3H to glucopyranosic unit (ClSO3H/GU), reaction time and reaction temperature on the degree of sulphonation (DS) and molecular weight (Mw) of products were studied. The structures of guar gum sulphate were investigated by GPC, FT-IR and UV-Visible spectroscopy. Activated partial thromboplastin time (APTT)assay showed that the guar gum sulphate could inhibit the intrinsic coagulant pathway. The anticoagulant activity strongly depended on the DS and Mw of polysaccharides. DS > 0.56 was essentialfor anticoagulant activity. The guar gum sulphate with the DS of 0.85 and the Mw of 3.40 x 10(4) had the best blood anticoagulant activity.
引用
收藏
页码：1085 / 1094
页数：10
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