The inhibition of human neuronal K+ currents by general anesthetic agents is altered by extracellular K+

被引：11
|
作者：
Friederich, P
Urban, BW
机构：
[1] Univ Bonn, Dept Anesthesiol, D-5300 Bonn, Germany
[2] Cornell Univ, Coll Med, Dept Anesthesiol, New York, NY USA
[3] Cornell Univ, Coll Med, Dept Physiol, New York, NY USA
来源：
MOLECULAR BRAIN RESEARCH | 1998年 / 60卷 / 02期
关键词：
anesthetic mechanisms; intravenous anesthetic; etomidate; propofol; ketamine; patch-clamp technique; whole cell; potassium; extracellular concentration; potassium current; human neuronal;
D O I：
10.1016/S0169-328X(98)00209-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We demonstrate for the first time that the extracellular potassium concentration influences the inhibition of human neuronal delayed rectifier potassium currents by general anesthetics. This observation suggests a modulatory role for extracellular potassium ions in the action of some general anesthetic agents. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：301 / 304
页数：4
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