Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to β-lactams

被引：121
|
作者：
Nishino, K
Yamada, J
Hirakawa, H
Hirata, T
Yamaguchi, A
机构：
[1] Osaka Univ, Inst Sci & Ind Res, Dept Cell Membrane Biol, Ibaraki, Osaka 5670047, Japan
[2] Japan Sci & Technol Corp, CREST, Ibaraki, Osaka 5670047, Japan
[3] Osaka Univ, Fac Pharmaceut Sci, Osaka 5650871, Japan
[4] Osaka Univ, Microbial Dis Res Inst, Dept Bacterial Infect, Osaka 5650871, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 09期
关键词：
D O I：
10.1128/AAC.47.9.3030-3033.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
AcrAB exports some beta-lactam antibiotics in the periplasm out of cells via an outer-membrane channel, TolC. It has been reported that eight drug transporters in Escherichia coli cooperate with TolC. In this study, the roles of the drug exporters of E. coli in beta-lactam resistance were examined. We found that five of five resistance-nodulation-cell division-type drug exporters confer beta-lactam antibiotic resistance, while no other drug exporters confer any beta-lactam resistance even when they cooperate with TolC.
引用
收藏
页码：3030 / 3033
页数：4
相关论文
共 50 条
  • [31] ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance
    Wanjiru Muriithi
    Lucy Wanjiku Macharia
    Carlos Pilotto Heming
    Juliana Lima Echevarria
    Atunga Nyachieo
    Paulo Niemeyer Filho
    Vivaldo Moura Neto
    Cancer Biology & Medicine, 2020, 17 (02) : 253 - 269
  • [32] ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance
    Wanjiru Muriithi
    Lucy Wanjiku Macharia
    Carlos Pilotto Heming
    Juliana Lima Echevarria
    Atunga Nyachieo
    Paulo Niemeyer Filho
    Vivaldo Moura Neto
    Cancer Biology & Medicine, 2020, (02) : 253 - 269
  • [33] ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance
    Muriithi, Wanjiru
    Macharia, Lucy Wanjiku
    Heming, Carlos Pilotto
    Echevarria, Juliana Lima
    Nyachieo, Atunga
    Niemeyer Filho, Paulo
    Neto, Vivaldo Moura
    CANCER BIOLOGY & MEDICINE, 2020, 17 (02) : 253 - 269
  • [34] Plasmid mediated multidrug resistance of clinical Escherichia coli isolates
    Mandal, Shyamapada
    DebMandal, Manisha
    Kumar, Nishith
    JUNDISHAPUR JOURNAL OF MICROBIOLOGY, 2011, 4 (03) : 207 - 208
  • [35] Genetic assessment of the role of AcrB βhairpins in the assembly of the TolC-AcrAB multidrug efflux pump of Escherichia coli
    Weeks, Jon W.
    Bavro, Vassiliy N.
    Misra, Rajeev
    MOLECULAR MICROBIOLOGY, 2014, 91 (05) : 965 - 975
  • [36] Diarrheagenic Escherichia coli with Multidrug Resistance in Cattle from Mexico
    Ortiz, Yaraymi
    Cerino, Brenda
    Moreno, Mauricio
    Yanez, Elizabeth
    Heredia, Norma
    Davila-Avina, Jorge
    Quezada, Teodulo
    Calle, Alexandra
    Garcia, Santos
    JOURNAL OF FOOD PROTECTION, 2024, 87 (04)
  • [37] Identifying Escherichia coli genes involved in intrinsic multidrug resistance
    Duo, Miao
    Hou, Shuyu
    Ren, Dacheng
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2008, 81 (04) : 731 - 741
  • [38] Escherichia coli with virulence factors and multidrug resistance in the Plankenburg River
    Lamprecht, Corne
    Romanis, Marco
    Huisamen, Nicola
    Carinus, Anneri
    Schoeman, Nika
    Sigge, Gunnar O.
    Britz, Trevor J.
    SOUTH AFRICAN JOURNAL OF SCIENCE, 2014, 110 (9-10) : 32 - 37
  • [39] Identifying Escherichia coli genes involved in intrinsic multidrug resistance
    Miao Duo
    Shuyu Hou
    Dacheng Ren
    Applied Microbiology and Biotechnology, 2008, 81 : 731 - 741
  • [40] The impact of multidrug resistance on the pathogenicity of Escherichia coli:: an experimental study
    Bristianou, Magdalini
    Panagou, Charalambos
    Adamis, Theodoros
    Raftogiannis, Maria
    Antonopoulou, Anastasia
    Chrisofos, Michael
    Galani, Irene
    Kanellakopoulou, Kyriaki
    Tsaganos, Thomas
    Giamarellos-Bourboulis, Evangelos J.
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2008, 31 (03) : 216 - 223
12345