Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to β-lactams

被引：121
|
作者：
Nishino, K
Yamada, J
Hirakawa, H
Hirata, T
Yamaguchi, A
机构：
[1] Osaka Univ, Inst Sci & Ind Res, Dept Cell Membrane Biol, Ibaraki, Osaka 5670047, Japan
[2] Japan Sci & Technol Corp, CREST, Ibaraki, Osaka 5670047, Japan
[3] Osaka Univ, Fac Pharmaceut Sci, Osaka 5650871, Japan
[4] Osaka Univ, Microbial Dis Res Inst, Dept Bacterial Infect, Osaka 5650871, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 09期
关键词：
D O I：
10.1128/AAC.47.9.3030-3033.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
AcrAB exports some beta-lactam antibiotics in the periplasm out of cells via an outer-membrane channel, TolC. It has been reported that eight drug transporters in Escherichia coli cooperate with TolC. In this study, the roles of the drug exporters of E. coli in beta-lactam resistance were examined. We found that five of five resistance-nodulation-cell division-type drug exporters confer beta-lactam antibiotic resistance, while no other drug exporters confer any beta-lactam resistance even when they cooperate with TolC.
引用
收藏
页码：3030 / 3033
页数：4
相关论文
共 50 条
  • [1] TolC-dependent exclusion of porphyrins in Escherichia coli
    Tatsumi, Ryoko
    Wachi, Masaaki
    JOURNAL OF BACTERIOLOGY, 2008, 190 (18) : 6228 - 6233
  • [2] Dynamic interplay of multidrug transporters with TolC for isoprenol tolerance in Escherichia coli
    Wang, Chonglong
    Yang, Liyang
    Shah, Asad Ali
    Choi, Eui-Sung
    Kim, Seon-Won
    SCIENTIFIC REPORTS, 2015, 5
  • [3] Multidrug resistance transporters in Escherichia coli
    Bibi, E
    Edgar, R
    Béjà, O
    Meller-Harel, Y
    Hillel, I
    MICROBIAL ECOLOGY AND INFECTIOUS DISEASE, 1999, : 276 - 283
  • [4] Dynamic interplay of multidrug transporters with TolC for isoprenol tolerance in Escherichia coli
    Chonglong Wang
    Liyang Yang
    Asad Ali Shah
    Eui-Sung Choi
    Seon-Won Kim
    Scientific Reports, 5
  • [5] Physiological Effects of TolC-Dependent Multidrug Efflux Pumps in Escherichia coli: Impact on Motility and Growth Under Stress Conditions
    Di Maso, Amanda M.
    Ruiz, Cristian
    MICROBIOLOGYOPEN, 2024, 13 (06):
  • [6] Propargylglycine-based antimicrobial compounds are targets of TolC-dependent efflux systems in Escherichia coli
    Roldan, Bec J.
    Pajarillo, Andrea O.
    Greenberg, Jacob D.
    Karlinsey, Joyce E.
    Cafiero, Mauricio
    Frawley, Elaine R.
    Peterson, Larryn W.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (02)
  • [7] Identification of Escherichia coli multidrug resistance transporters involved in anthocyanin biosynthesis
    Wu, Xia
    Chen, Rongxia
    Liang, Ping
    Zha, Jian
    FRONTIERS IN MICROBIOLOGY, 2024, 15
  • [8] Reduction of Cellular Stress by TolC-Dependent Efflux Pumps in Escherichia coli Indicated by BaeSR and CpxARP Activation of spy in Efflux Mutants
    Rosner, Judah L.
    Martin, Robert G.
    JOURNAL OF BACTERIOLOGY, 2013, 195 (05) : 1042 - 1050
  • [9] Quorum sensing and multidrug transporters in Escherichia coli
    Yang, S
    Lopez, CR
    Zechiedrich, EL
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (07) : 2386 - 2391
  • [10] Multidrug resistance pump AcrAB-TolC is required for high-level, Tet(A)-mediated tetracycline resistance in Escherichia coli
    de Cristobal, Ricardo E.
    Vincent, Paula A.
    Salomon, Raul A.
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (01) : 31 - 36
12345