α-aryloxy-α-methylhydrocinnamic acids:: A novel class of PPARα/γ dual agonists.

被引:0
|
作者
Xu, YP [1 ]
Brooks, DA [1 ]
Dominianni, SJ [1 ]
Etgen, G [1 ]
Jones, SB [1 ]
Kauffman, RF [1 ]
Montrose-Rafizadeh, C [1 ]
Rito, CJ [1 ]
Shuker, AJ [1 ]
Tripp, A [1 ]
Winneroski, LL [1 ]
Zink, RW [1 ]
McCarthy, J [1 ]
机构
[1] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
362-MEDI
引用
收藏
页码:U68 / U68
页数:1
相关论文
共 50 条
  • [1] Design and synthesis of α-aryloxy-α-methylhydrocinnamic acids:: A novel class of dual peroxisome proliferator-activated receptor α/γ agonists
    Xu, YP
    Rito, CJ
    Etgen, GJ
    Ardecky, RJ
    Bean, JS
    Bensch, WR
    Bosley, JR
    Broderick, CL
    Brooks, DA
    Dominianni, SJ
    Hahn, PJ
    Liu, S
    Mais, DE
    Montrose-Rafizadeh, C
    Ogilvie, KM
    Oldham, BA
    Peters, M
    Rungta, DK
    Shuker, AJ
    Stephenson, GA
    Tripp, AE
    Wilson, S
    Winneroski, LL
    Zink, R
    Kauffman, RF
    McCarthy, JR
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (10) : 2422 - 2425
  • [2] Antitumor activity of a novel series of α-aryloxy-α-methylhydrocinnamic acid derivatives as PPAR gamma agonists against a panel of human cancer cell lines
    Xishan Xiong
    Yangliang Ye
    Lili Fu
    Bing Dai
    Jieqiong Liu
    Jieshuang Jia
    Jing Tang
    Lin Li
    Li Wang
    Jianhua Shen
    Changlin Mei
    [J]. Investigational New Drugs, 2009, 27 : 223 - 232
  • [3] Antitumor activity of a novel series of α-aryloxy-α-methylhydrocinnamic acid derivatives as PPAR gamma agonists against a panel of human cancer cell lines
    Xiong, Xishan
    Ye, Yangliang
    Fu, Lili
    Dai, Bing
    Liu, Jieqiong
    Jia, Jieshuang
    Tang, Jing
    Li, Lin
    Wang, Li
    Shen, Jianhua
    Mei, Changlin
    [J]. INVESTIGATIONAL NEW DRUGS, 2009, 27 (03) : 223 - 232
  • [4] Discovery of potent PPARα and PPARγ dual agonists.
    Oplinger, JA
    Spearing, PK
    Collins, JL
    Plunket, KD
    Lewis, M
    Oliver, W
    Tong, T
    Alva, G
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U42 - U42
  • [5] Novel Pirinixic Acids as PPARα Preferential Dual PPARα/γ Agonists
    Zettl, Heiko
    Dittrich, Michaela
    Steri, Ramona
    Proschak, Ewgenij
    Rau, Oliver
    Steinhilber, Dieter
    Schneider, Gisbert
    Laemmerhofer, Michael
    Schubert-Zsilavecz, Manfred
    [J]. QSAR & COMBINATORIAL SCIENCE, 2009, 28 (05): : 576 - 586
  • [6] Discovery of potent orally active aryloxazolidinediones class of dual PPAR gamma and alpha agonists.
    Desai, RC
    Gratale, DF
    Han, W
    Koyama, H
    Metzger, E
    Lombardo, VK
    Berger, JP
    MacNaul, KL
    Doebber, TW
    Zhou, GC
    Leung, K
    Franklin, R
    Moller, DE
    Sahoo, SP
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U176 - U177
  • [7] Design and synthesis of a novel class of dual PPARγ/δ agonists
    Gonzalez, Isabel C.
    Lamar, Jason
    Iradier, Fatima
    Xu, Yanping
    Winneroski, Leonard L.
    York, Jeremy
    Yumibe, Nathan
    Zink, Richard
    Montrose-Rafizadeh, Chahrzad
    Etgen, Gary J.
    Broderick, Carol L.
    Oldham, Brian A.
    Mantlo, Nathan
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (04) : 1052 - 1055
  • [8] A novel, structurally unique class of muscarinic agonists.
    Nason, DM
    Lee, MH
    Biggers, CK
    Ward, KM
    Nowakowski, JT
    Yohannes, D
    Liston, DR
    Villalobos, A
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 212 : 81 - MEDI
  • [9] Design and synthesis of novel, potent, and selective PPAR delta agonists.
    Conner, SE
    Zhu, GX
    Montrose-Rafizadeh, C
    Barr, RJ
    Jett, D
    Zink, RW
    Yumibe, N
    Mantlo, NB
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U940 - U940
  • [10] Design, development and evaluation of novel dual PPARδ/PPARγ agonists
    Gathiaka, Symon
    Nanayakkara, Gayani
    Boncher, Tracey
    Acevedo, Orlando
    Wyble, Johnathon
    Patel, Sagar
    Patel, Akash
    Shane, Mary Elizabeth
    Bonkowski, Blake
    Wieczorek, Jason
    Rong, Yinghui
    Huggins, Kevin
    Smith, Forest
    Amin, Rajesh H.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (03) : 873 - 879