L-Asparaginase-Induced Hepatotoxicity Treated Successfully With L-Carnitine and Vitamin B Infusion

被引：5

作者：

Lee, Christina ^{[1
]}

Leventhal, Thomas M. ^{[2
]}

Anugwom, Chimaobi M. ^{[3
]}

机构：

[1] Univ Minnesota, Sch Med, Internal Med, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Div Gastroenterol Hepatol & Nutr, Transplant Hepatol & Crit Care Med, Minneapolis, MN USA

[3] Univ Minnesota, Gastroenterol & Hepatol, Minneapolis, MN USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2021年 / 13卷 / 08期

关键词：

severe hepatotoxicity; drug-induced hepatotoxicity; cholangiopathy; acute lymphocytic leukemia; asparaginase; l-carnitine; vitamin b;

D O I：

10.7759/cureus.16917

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Asparaginase plays an integral role in chemotherapy for acute lymphoblastic leukemia (ALL). We present a 69-year old woman with refractory ALL, who developed asparaginase-induced hepatotoxicity and cholangiopathy after starting intravenous PEG-L-asparaginase-based chemotherapy. The patient was ultimately treated with the combination of L-carnitine and vitamin B complex, resulting in normalization of liver enzymes levels. This case highlights the consideration of PEG-L asparaginase chemotherapy-induced liver steatosis, injury, and cholangiopathy as well as the role of L-carnitine and vitamin B complex as treatment.

引用

页数：7

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