An Interference Study with Different Working Potentials for an Amperometric Glucose Sensor

The correlation between working potential and amperometric response using an amperometric glucose sensor was investigated by amperometry. Influence of some potential interferents including bilirubin, creatinine, and uric acid was studied in real human blood samples. The test strips can provide correct glucose concentration values for an amperometric glucose sensor in the absence of interferents. The influence of interferents with different working potentials from +0.3 V to +0.7 V was considered based on average glucose values and coefficient of variation (CV). It shows low deviation at +0.5 V and +0.7 V for average glucose values and low CV values at +0.4 V for coefficient of variation. Optimization of working potentials can be further considered for various amperometric glucose sensors in the literature by the simple method.