The gender differences in health effects of environmental cadmium exposure and potential mechanisms

被引：106
|
作者：
Nishijo, M
Satarug, S
Honda, R
Tsuritani, I
Aoshima, K
机构：
[1] Kanazawa Med Univ, Dept Publ Hlth, Uchinada, Ishikawa 9200293, Japan
[2] Natl Res Ctr Environm Toxicol, Brisbane, Qld, Australia
[3] Kanazawa Med Univ, Dept Hyg, Kanazawa, Ishikawa, Japan
[4] Toyama Med Pharmaceut Univ, Dept Publ Hlth, Toyama, Japan
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2004年 / 255卷 / 1-2期
关键词：
cadmium; gender difference; renal tubular dysfunction; kidney sensitivity; bone injury;
D O I：
10.1023/B:MCBI.0000007264.37170.39
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
On a viewpoint of gender differences in Cd body burden and its health effects, we reviewed the population- based research including our own which conducted in Japan, Thailand, Australia, Poland, Belgium and Sweden to assess health effects of human exposure to environmental cadmium and their potential mechanisms. As a result, six risk factors in Cd health effects in women have been identified; ( 1) more serious type of renal tubular dysfunction, ( 2) difference in calcium metabolism and its regulatory hormones, ( 3) kidney sensitivity; difference in P450 phenotype, ( 4) pregnancy, ( 5) body iron store status, and ( 6) genetic factors. Further studies of Cd toxicity targeted to women would now appear necessary.
引用
收藏
页码：87 / 92
页数：6
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