Pd-Catalyzed Dearomatization of Indole Derivatives via Intermolecular Heck Reactions

被引：33
|
作者：
Yang, Ping [1 ]
Xu, Ren-Qi [1 ]
Zheng, Chao [1 ]
You, Shu-Li [1 ]
机构：
[1] Chinese Acad Sci, Univ Chinese Acad Sci, State Key Lab Organometall Chem, Ctr Excellence Mol Synth,Shanghai Inst Organ Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2020年 / 38卷 / 03期
关键词：
ASYMMETRIC DEAROMATIZATION; RECENT PROGRESS; PHENOL DEAROMATIZATION; ARYLATION; ELEMENTS; LIGANDS; HALIDES;
D O I：
10.1002/cjoc.201900509
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The Summary of main observation and conclusion Pd-catalyzed intermolecular dearomative Heck reaction of indoles with aryl iodides is described. The challenges on both reactivity and regioselectivity are addressed by the judicious regulation of the geometric and electronic properties of the substrates. An array of indoline derivatives bearing C2-quaternary center is obtained in good to excellent yields (up to 93%) with exclusive regioselectivity under operationally simple conditions. The mechanistic proposal is supported by detailed DFT calculations.
引用
收藏
页码：235 / 241
页数：7
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