MECHANICAL TENSILE STRAIN STIMULATION OF CHONDROCYTES AND MENISCUS CELLS IN THERMO-RESPONSIVE HYDROGEL

被引：0

作者：

Chen, Jyh-Ping ^{[1
]}

Cheng, Tai-Hong ^{[1
]}

机构：

[1] Dept Chem & Mat Engn, Taiyuan 333, Taiwan

来源：

FIRST INTERNATIONAL SYMPOSIUM ON BIOENGINEERING (ISOB 2011), PROCEEDINGS | 2011年

关键词：

EXTRACELLULAR-MATRIX; ARTICULAR-CARTILAGE; BIOSYNTHESIS;

D O I：

10.3850/978-981-08-7615-9_TE05

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Temperature-responsive hydrogel scaffold containing chitosan and hyaluronic acid was used to entrap primary chondrocytes and meniscus cells. The effect of dynamic tensile strain on the cells/hydrogel constructs was evaluated by measuring cell proliferation, biosynthetic activity, and viability. The results demonstrated that mechanical deformation resulted in substantial increase in glycosaminoglycan and collagen productions over static controls while not significantly affecting cell proliferation and viability.

引用

页码：306 / 313

页数：8

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