Predictive value of MTT assay as an in vitro chemosensitivity testing for gastric cancer:: One institution's experience

被引：29
|
作者：
Wu, Bin [2 ]
Zhu, Jin-Shui [1 ]
Zhang, Yi [2 ]
Shen, Wei-Ming [2 ]
Zhang, Qiang [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Dept Gastroenterol, Shanghai Hosp Affiliated 6, Shanghai 200223, Peoples R China
[2] Shanghai Jiao Tong Univ, Dept Pharm, Shanghai Hosp Affiliated 6, Shanghai 200223, Peoples R China
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 19期
关键词：
gastric cancer; chemosensitivity testing; chemotherapy; MTT assay; survival rate;
D O I：
10.3748/wjg.14.3064
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
AIM: To investigate the predictive clinical value of in vitro 3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay for directing chemosensitivity in patients with gastric cancer. METHODS: Results of a total of 353 consecutive patients with gastric cancer treated with MTT-directed chemotherapy or physician's empirical chemotherapy from July 1997 to April 2003 were reviewed and analyzed retrospectively. RESULTS: The overall 5-year survival rate of MTT-sensitive group (MSG) and control group (CG) was 47.5% and 45.1%, respectively. The results of subgroup analysis with Cox proportional-hazards model were favorable for the MSG-sensitive group. However, no statistically significant difference in survival rate was observed between the two groups. CONCLUSION: Individualized chemotherapy based on in vitro MTT assay is beneficial, but needs to be confirmed by further randomized controlled trials. (C) 2008 WJG. All rights reserved.
引用
收藏
页码：3064 / 3068
页数：5
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