Differential effects of IL-2 and IL-15 on expression of IL-2 receptor α

被引：16
|
作者：
Alileche, A [1 ]
Goldman, CK [1 ]
Waldmann, TA [1 ]
机构：
[1] NCI, Metab Branch, NIH, Bethesda, MD 20892 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 285卷 / 05期
关键词：
IL-2; IL-15; receptor; expression; transcription; translocation; cytokines; cytokines receptors; cellular activation; NK cells;
D O I：
10.1006/bbrc.2001.5332
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
IL-2 and IL-15 have overlapping functions since they share the IL-2R beta gamma receptor complex. However, each cytokine has a private a receptor namely IL-2R alpha for IL-2 and IL-15R alpha for IL-15. As a consequence the effects of the two cytokines may differ. We describe the differential effects of the two cytokines regarding the induction of cell surface expression of the IL-2R alpha subunit on YT-1 cells. Both cytokines induced transcription of the IL-2R alpha gene. Furthermore translation of IL-2R alpha leading to intracellular expression of the receptor was observed following either IL-2 or IL-15 addition. However, only IL-15 was associated with the induction of cell surface expression of IL-2R alpha. With IL-2 there appears to be an impediment to the translocation of IL-2R alpha to the cell membrane. Since surface expression of IL-2R alpha is a key element in the formation of the high affinity IL-2 receptor, translocation of IL-2R alpha to the membrane represents another level of control of the immune response in addition to regulation of IL-2R alpha transcription and translation.
引用
收藏
页码：1302 / 1308
页数：7
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