Synthesis and properties of 18F-labeled potential myocardial blood flow tracers

被引：20
|
作者：
Studenov, AR [1 ]
Berridge, MS
机构：
[1] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA
[3] Univ Hosp Cleveland, Cleveland, OH 44106 USA
来源：
NUCLEAR MEDICINE AND BIOLOGY | 2001年 / 28卷 / 06期
关键词：
fluorine-18; perfusion heart; myocardium; acetylcholinesterase;
D O I：
10.1016/S0969-8051(01)00233-5
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
PET centers without particle accelerators make clinical PET widely available at reduced cost. For myocardial perfusion tracers, these satellite PET centers are limited to generator- produced Rb-82(+) and Cu-62[PTSM]. Their limitations motivate a search for transportable alternatives. In search of new tracers we have synthesized several F-18-labeled amines and quaternary ammonium salts. Among them, 4-[F-18]fluorotri-N-methylanilinium ([F-18]FTMA) has flow-tracing proper-ties. The compound is functional, but has properties that justify a continued search. (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：683 / 693
页数：11
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