Synthesis and biological activity of Mannich bases of certain 1,2-pyrazolines

被引：0
|
作者：
Udupi, RH [1 ]
Bhat, AR
Kumar, K
机构：
[1] VL Coll Pharm, Dept Pharmaceut Chem, Raichur 584101, India
[2] Coll Pharmaceut Sci, Manipal 576119, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 1998年 / 8卷 / 02期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The hydroxy pyrazolines were reacted with sulfa drugs and other compounds of biological interest containing free amino group in presence of formaldehyde when Mannich bases of 1,2-pyrazolines IIa-I were obtained. The compounds were characterized by elemental analysis, UV, IR and NMR spectral studies. All the newly synthesized compounds have been screened for antimicrobial activity and few compounds for antiinflammatory activity. Compound Ilk exhibited significant edema inhibiting activity.
引用
收藏
页码：143 / 146
页数：4
相关论文
共 50 条
  • [1] Utility of Ketonic Mannich Bases in Synthesis of Some New Functionalized 2-Pyrazolines
    Afsah, Elsayed M.
    Keshk, Eman M.
    Abdel-Rahman, Abdel-Rahman H.
    Jomah, Najla F.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (01) : 326 - 334
  • [2] Mannich bases as synthetic intermediates: Synthesis of 3- and 4-functionalized 2-pyrazolines
    Afsah, Elsayed M.
    Kandeel, Ez-el-Din M.
    Khalifa, Mona M.
    Hammouda, Waleed M.
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2007, 62 (04): : 540 - 548
  • [3] Mannich bases as synthetic intermediates: Synthesis of 3- and 4-functionalized 2-pyrazolines
    Afsah, Elsayed M.
    Kandeel, Ez-El-Din M.
    Khalifa, Mona M.
    Hammouda, Waleed M.
    Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2007, 62 (04): : 540 - 548
  • [4] Synthesis and biological activity of some Mannich bases
    Kalluraya, B
    Isloor, AM
    Chimbalkar, RM
    Shenoy, S
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2001, 10 (03) : 239 - 240
  • [5] Synthesis and antiproliferative activity of imidazo[1,2-a]pyrimidine Mannich bases
    Aeluri, Raghunath
    Alla, Manjula
    Polepalli, Sowjanya
    Jain, Nishant
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 100 : 18 - 23
  • [6] Synthesis and Biological Activity of Important Phenolic Mannich Bases
    Kousar, Fareeha
    Nosheen, Sofia
    Zahra, Sayeda Nida
    Kousar, Summaira
    Jahan, Nazish
    ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (01) : 59 - 62
  • [7] Synthesis and antibacterial activity of 2-pyrazolines and their related compounds
    Panchal, JM
    Desai, KR
    ASIAN JOURNAL OF CHEMISTRY, 2000, 12 (02) : 609 - 611
  • [8] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF SOME PYRROLOPYRAZOLES AND 2-PYRAZOLINES
    EAD, HA
    HASSANEEN, HM
    ABDALLAH, MA
    MOUSA, HAH
    ARCHIV DER PHARMAZIE, 1991, 324 (01) : 35 - 37
  • [9] Synthesis and Biological Activity of Some Aminobenzylated Mannich Bases of Benzaldehyde
    Chaluvaraju, K. C.
    Ishwarbhat, K.
    ASIAN JOURNAL OF CHEMISTRY, 2009, 21 (06) : 4960 - 4962
  • [10] Synthesis and antibacterial activity of some fluorine containing 2-pyrazolines
    Desai, MD
    Desai, KK
    ASIAN JOURNAL OF CHEMISTRY, 2002, 14 (02) : 995 - 998
12345