Synthesis of Highly Substituted 2-Aminopyridines with Vinyl Azides, Isonitriles, and Ketones

被引：1

作者：

Chang, Wenxu ^{[1
,2
]}

Li, Zongyang ^{[1
,2
]}

Yuan, Chenhui ^{[1
,2
]}

Liu, Xinying ^{[1
,2
]}

Feng, Jiyao ^{[1
,2
]}

Pang, Sen ^{[1
,2
]}

Duan, Liusheng ^{[1
,2
]}

Zhang, Zhenhua ^{[1
,2
]}

机构：

[1] China Agr Univ, Coll Agron & Biotechnol, Beijing 100193, Peoples R China

[2] China Agr Univ, Coll Sci, Beijing 100193, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2022年 / 17卷 / 09期

基金：

中国国家自然科学基金;

关键词：

vinyl azides; vinyl carbodiimide; 2-aminopyridine; cascade reaction; CRYSTAL; CYCLIZATIONS; DESIGN; GROWTH;

D O I：

10.1002/asia.202200083

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We developed a facile, efficient method for synthesizing highly substituted 2-aminopyridines from unstable vinyl carbodiimides generated in situ in a one-pot transformation. A series of novel highly substituted 3-functionalized 2-aminopyridines were produced in good yields. Reaction mechanism studies, which included control experiments and density-functional theory (DFT) calculations, demonstrated that Rh and potassium carbonate played key roles in the cyclization step.

引用

页数：6

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