Roles of the prostaglandin E2 receptors EP subtypes in Alzheimer's disease

被引：13

作者：

Wei, Li-Li ^{[1
]}

Shen, Yue-Di ^{[2
]}

Zhang, Ying-Chun ^{[1
]}

Hu, Xing-Yue ^{[3
]}

Lu, Pei-Ling ^{[3
]}

Wang, Li ^{[3
]}

Chen, Wei ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Dept Mental Hlth, Sir Run Run Shaw Hosp, Hangzhou 310016, Zhejiang, Peoples R China

[2] Hangzhou Normal Univ, Sch Med, Dept Diagnost, Affiliated Hosp, Hangzhou 310015, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sch Med, Dept Neurol, Sir Run Run Shaw Hosp, Hangzhou 310016, Zhejiang, Peoples R China

来源：

NEUROSCIENCE BULLETIN | 2010年 / 26卷 / 01期

关键词：

inflammation; Alzheimer's disease; prostaglandin E-2; prostaglandin E-2 receptors; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CEREBRAL-ISCHEMIA; MICROGLIAL ACTIVATION; PROSTANOID RECEPTORS; SIGNALING PATHWAY; NEURONAL SURVIVAL; BETA PHAGOCYTOSIS; CORTICAL-NEURONS; OXIDATIVE DAMAGE; INNATE IMMUNITY;

D O I：

10.1007/s12264-010-0703-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuroinflammation has always been of concern in the pathogenesis of Alzheimer's disease (AD). As a major inflammatory mediator, prostaglandin E-2 (PGE(2)) plays an important role in the inflammatory process of AD. Up to now, there is still controversy on the neuroprotective or neurotoxic role of PGE(2). However, the role of PGE(2) in neurodegeneration may be far more complex, due to the 4 EP receptor subtypes. This article aims to summarize the relationship between PGE(2) receptor EP subtypes and AD. It is believed that a better understanding of the PGE(2) receptor EP subtypes may help to clarify the relation between inflammation and AD, and to develop novel therapeutic strategies targeting specific EP receptor for AD treatment.

引用

页码：77 / 84

页数：8

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