Pd-Catalyzed Regioselective Branched Hydrocarboxylation of Terminal Olefins with Formic Acid

被引：14
|
作者：
Ren, Wenlong [1 ]
Wang, Mingzhou [1 ]
Guo, Jianqiong [1 ]
Zhou, Jintao [1 ]
Chu, Jianxiao [1 ]
Shi, Yuan [1 ]
Shi, Yian [1 ]
机构：
[1] Changzhou Univ, Inst Nat & Synthet Organ Chem, Changzhou 213164, Peoples R China
来源：
ORGANIC LETTERS | 2022年 / 24卷 / 03期
基金：
中国国家自然科学基金;
关键词：
PALLADIUM(II) COMPLEXES; CARBOXYLIC-ACIDS; CARBON-MONOXIDE; ARYL OLEFINS; HYDROXYCARBONYLATION; ALKENES; CARBONYLATION; ALKYNES; STYRENE; METHOXYCARBONYLATION;
D O I：
10.1021/acs.orglett.1c04231
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A regioselective Pd-catalyzed hydrocarboxylation of terminal olefins with HCOOH is described. A wide variety of branched carboxylic acids can readily be obtained with high regioselectivities under mild reaction conditions. The reaction is operationally simple and requires no handling of toxic CO. The ligand and LiCl are important factors for reaction reactivity and selectivity.
引用
收藏
页码：886 / 891
页数：6
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