DNA methylation in spermatogenesis and male infertility

被引：56
|
作者：
Cui, Xiangrong [1 ,2 ,3 ]
Jing, Xuan [4 ]
Wu, Xueqing [1 ,2 ]
Yan, Meiqin [1 ,2 ]
Li, Qiang [1 ,2 ]
Shen, Yan [1 ,2 ]
Wang, Zhenqiang [1 ,2 ]
机构：
[1] Childrens Hosp Shanxi, Reprod Med Ctr, 13 Xinmin North St, Taiyuan 030000, Shanxi, Peoples R China
[2] Women Hlth Ctr Shanxi, 13 Xinmin North St, Taiyuan 030000, Shanxi, Peoples R China
[3] Ctr Hosp Linfen, Div Clin Microbiol, Linfen 041000, Shanxi, Peoples R China
[4] Shanxi Prov Peoples Hosp, Clin Lab, Taiyuan 030001, Shanxi, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2016年 / 12卷 / 04期
关键词：
DNA methylation; male infertility; spermatogenesis; epigenetics; GERM-CELL DEVELOPMENT; ASSISTED REPRODUCTIVE TECHNOLOGY; IN-VITRO FERTILIZATION; DE-NOVO METHYLATION; IMPRINTED GENES; EPIGENETIC INHERITANCE; STEM-CELLS; METHYLTRANSFERASE EXPRESSION; IMPAIRED SPERMATOGENESIS; DEOXYRIBONUCLEIC-ACID;
D O I：
10.3892/etm.2016.3569
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Infertility is a significant problem for human reproduction, with males and females equally affected. However, the molecular mechanisms underlying male infertility remain unclear. Spermatogenesis is a highly complex process involving mitotic cell division, meiosis cell division and spermiogenesis; during this period, unique and extensive chromatin and epigenetic modifications occur to bring about specific epigenetic profiles in spermatozoa. It has recently been suggested that the dysregulation of epigenetic modifications, in particular the methylation of sperm genomic DNA, may serve an important role in the development of numerous diseases. The present study is a comprehensive review on the topic of male infertility, aiming to elucidate the association between sperm genomic DNA methylation and poor semen quality in male infertility. In addition, the current status of the genetic and epigenetic determinants of spermatogenesis in humans is discussed.
引用
收藏
页码：1973 / 1979
页数：7
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