NOCICEPTIN/ORPHANIN FQ PEPTIDE RECEPTOR ANTAGONIST RESCUES TRAUMATIC BRAIN INJURY-INDUCED IMPAIRED CEREBRAL BLOOD FLOW

被引：0
|
作者：
Al Yacoub, Omar [1 ]
Tarantini, Stefano [2 ,3 ,4 ]
Awwad, Hibah [1 ]
Csiszar, Anna [2 ,3 ]
Standifer, Kelly [1 ]
机构：
[1] Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Dept Pharmaceut Sci, Oklahoma City, OK 73190 USA
[2] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, Oklahoma City, OK 73190 USA
[3] Univ Oklahoma, Hlth Sci Ctr, Oklahoma Ctr Gerosci & Hlth Brain Aging, Oklahoma City, OK USA
[4] Stephenson Canc Ctr, Oklahoma City, OK USA
来源：
JOURNAL OF NEUROTRAUMA | 2022年 / 39卷 / 11-12期
关键词：
Concussion/mTBI; Therapeutics/Drug Discovery; Cerebral Blood Flow; Receptor Mediated/Signaling;
D O I：
暂无
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
P143
引用
收藏
页码：A63 / A64
页数：2
相关论文
共 50 条
  • [1] The Nociceptin/Orphanin FQ peptide receptor antagonist, SB-612111, improves cerebral blood flow in a rat model of traumatic brain injury
    Al Yacoub, Omar N.
    Tarantini, Stefano
    Zhang, Yong
    Csiszar, Anna
    Standifer, Kelly M.
    [J]. FRONTIERS IN PHARMACOLOGY, 2023, 14
  • [2] Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and Nociceptin Opioid Peptide Receptor Expression within 24 Hours
    Al Yacoub, Omar N.
    Zhang, Yong
    Patankar, Panini S.
    Standifer, Kelly M.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (03)
  • [3] Traumatic brain injury induces nociceptin/orphanin FQ expression in neurons of the rat cerebral cortex
    Witta, J
    Buzas, B
    Cox, BM
    [J]. JOURNAL OF NEUROTRAUMA, 2003, 20 (06) : 523 - 532
  • [4] Post-blast treatment with Nociceptin/Orphanin FQ peptide (NOP) receptor antagonist reduces brain injury-induced hypoxia and signaling proteins in vestibulomotor-related brain regions
    Awwad, Hibah O.
    Durand, Cindy D.
    Gonzalez, Larry P.
    Tompkins, Paul
    Zhang, Yong
    Lerner, Megan R.
    Brackett, Daniel J.
    Sherry, David M.
    Awasthi, Vibhudutta
    Standifer, Kelly M.
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2018, 340 : 183 - 194
  • [5] Loss of Nociceptin/Orphanin FQ peptide receptor protects against traumatic brain injury (TBI)-induced deficits in male and female rats
    Al Yacoub, Omar
    Baier, Matthew
    Awwad, Hibah
    Standifer, Kelly
    [J]. FASEB JOURNAL, 2021, 35
  • [6] UFP-101, a peptide antagonist selective for the nociceptin/orphanin FQ receptor
    Calo, G
    Guerrini, R
    Rizzi, A
    Salvadori, S
    Burmeister, M
    Kapusta, DR
    Lambert, DG
    Regoli, D
    [J]. CNS DRUG REVIEWS, 2005, 11 (02): : 97 - 112
  • [7] MicroPET studies in rhesus macaques of brain Nociceptin/Orphanin FQ peptide receptor occupancy with nociceptin
    Shao, Xia
    Fawaz, Maria
    Saccone, Phillip
    Stewart, Megan
    Kilbourn, Michael
    Woods, James
    Scott, Peter
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2014, 55
  • [8] Therapeutic potential of nociceptin/orphanin FQ peptide (NOP) receptor modulators for treatment of traumatic brain injury, traumatic stress, and their co-morbidities
    Al Yacoub, Omar N.
    Awwad, Hibah O.
    Zhang, Yong
    Standifer, Kelly M.
    [J]. PHARMACOLOGY & THERAPEUTICS, 2022, 231
  • [9] Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24
    Fischetti, Carmela
    Camarda, Valeria
    Rizzi, Anna
    Pela, Michela
    Trapella, Claudio
    Guerrini, Remo
    McDonald, John
    Lambert, David G.
    Salvadori, Severo
    Regoli, Domenico
    Calo, Girolamo
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 614 (1-3) : 50 - 57
  • [10] Antihyperalgesic Effect of Buprenorphine Involves Nociceptin/Orphanin FQ Peptide-Receptor Activation in Rats With Spinal Nerve Injury-Induced Neuropathy
    Takahashi, Tomoko
    Okubo, Kazumasa
    Kojima, Shota
    Nishikawa, Hiroyuki
    Takemura, Motohide
    Tsubota-Matsunami, Maho
    Sekiguchi, Fumiko
    Kawabata, Atsufumi
    [J]. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 122 (01) : 51 - 54
12345