Antihyperalgesic Effect of Buprenorphine Involves Nociceptin/Orphanin FQ Peptide-Receptor Activation in Rats With Spinal Nerve Injury-Induced Neuropathy

被引：11
|
作者：
Takahashi, Tomoko [1 ]
Okubo, Kazumasa [1 ]
Kojima, Shota [1 ]
Nishikawa, Hiroyuki [1 ]
Takemura, Motohide [2 ]
Tsubota-Matsunami, Maho [1 ]
Sekiguchi, Fumiko [1 ]
Kawabata, Atsufumi [1 ]
机构：
[1] Kinki Univ, Sch Pharm, Div Pharmacol & Pathophysiol, Higashiosaka, Osaka 5778502, Japan
[2] Osaka Univ, Grad Sch Dent, Dept Oral Anat & Neurobiol, Suita, Osaka 5650871, Japan
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2013年 / 122卷 / 01期
关键词：
buprenorphine; nociceptin/orphanin FQ peptide receptor; neuropathic pain; PAIN; MODELS;
D O I：
10.1254/jphs.13029SC
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We evaluated the effect of buprenorphine, a mixed agonist for mu-opioid receptors and nociceptin/orphanin FQ peptide (NOP) receptors, in neuropathic rats, using the paw pressure test. Buprenorphine, administered i.p. at 50, but not 20 mu g/kg, exhibited naloxone-reversible analgesic activity in naive rats. In contrast, buprenorphine at 0.5 - 20 mu g/kg produced a naloxone-sensitive antihyperalgesic effect in the L5 spinal nerve injured neuropathic rats. Intrathecal injection of [N-Phe(1)]nociceptin(1-13)NH2, a NOP-receptor antagonist, reversed the effect of buprenorphine in neuropathic rats, but not in naive rats. Together, buprenorphine suppresses neuropathic hyperalgesia by activating NOP and opioid receptors, suggesting its therapeutic usefulness in treatment of neuropathic pain.
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页码：51 / 54
页数：4
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