Neoplastic transformation of endocervicosis into an extraovarian mucinous cystadenocarcinoma

被引：9
|
作者：
Kruse, Arnold-Jan [1 ,2 ]
Slangen, Brigitte [1 ,2 ]
Dunselman, Gerard A. [1 ,2 ]
Pirens, Tina
Bakers, Frans C. H. [4 ]
Baak, Jan P. A. [5 ,6 ,7 ]
Van de Vijver, Koen [1 ,3 ]
机构：
[1] Univ Maastricht, Maastricht Univ Med Ctr, Sch Oncol & Dev Biol, GROW, NL-6202 AZ Maastricht, Netherlands
[2] Maastricht Univ Med Ctr, Dept Obstet & Gynaecol, NL-6202 AZ Maastricht, Netherlands
[3] Maastricht Univ Med Ctr, Dept Pathol, NL-6202 AZ Maastricht, Netherlands
[4] Maastricht Univ Med Ctr, Dept Radiol, NL-6202 AZ Maastricht, Netherlands
[5] Stavanger Univ Hosp, Dept Pathol, Stavanger, Netherlands
[6] Univ Bergen, Gade Inst, Bergen, Norway
[7] Free Univ Amsterdam, Amsterdam, Netherlands
来源：
HUMAN PATHOLOGY | 2011年 / 42卷 / 05期
关键词：
Endocervicosis; Mucinous cystadenocarcinoma; KRAS; Extraovarian; URINARY-BLADDER; OVARIAN-CANCER; ADENOCARCINOMA; CARCINOMA; DISEASE; TUMORS;
D O I：
10.1016/j.humpath.2010.08.017
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Although extraovarian mucinous cystadenocarcinomas resemble primary ovarian carcinomas, both histologically and clinically, their specific etiology is not clear. This is the first report to show neoplastic transformation of endocervicosis into an extraovarian mucinous cystadenocarcinoma. The histologic spectrum and specific KRAS mutational analysis for this tumor were the same as for their ovarian counterparts. This supports a mullerian origin and the current approach to extrapolate the results from ovarian mucinous cystadenocarcinoma trials in prescribing treatment for patients with extraovarian mucinous cystadenocarcinomas. (C) 2011 Elsevier Inc. All rights reserved,
引用
收藏
页码：743 / 748
页数：6
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