Ring-Closing Metathesis Approaches for the Solid-Phase Synthesis of Cyclic Peptoids

被引：46

作者：

Khan, Sharaf Nawaz ^{[1
]}

Kim, Arim ^{[1
]}

Grubbs, Robert H. ^{[2
]}

Kwon, Yong-Uk ^{[1
]}

机构：

[1] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea

[2] CALTECH, Div Chem & Chem Engn, Arnold & Mabel Beckman Lab Chem Synth, Pasadena, CA 91125 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 07期

关键词：

PASSIVE MEMBRANE-PERMEABILITY; OLEFIN METATHESIS; PEPTIDOMIMETIC OLIGOMERS; BIOACTIVE PEPTIDES; DICARBA-ANALOGS; SURROGATE; CONSTRUCTION; INHIBITOR; HELICES; ACID;

D O I：

10.1021/ol200226z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclic peptoids were efficiently synthesized on a solid phase in high yields utilizing ring-closing metathesis (RCM). This method should be a valuable tool for easy access to cyclic peptoid libraries and various cyclic compounds.

引用

页码：1582 / 1585

页数：4

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