POSSIBLE ROLE OF THE ULTRA-RAPID DELAYED RECTIFIER POTASSIUM CURRENT (IKUR) IN ACTION POTENTIAL REPOLARISATION IN RABBIT HEART

被引：2
|
作者：
Cui, Y. [1 ]
Wilson, C. [1 ]
Turner, S. [1 ]
Graham, S. [1 ]
McMahon, N. [1 ]
Heath, B. [1 ]
机构：
[1] GlaxoSmithKline Inc, Safety Pharmacol, Ware, Herts, England
来源：
HEART | 2011年 / 97卷 / 01期
关键词：
D O I：
10.1136/hrt.2010.213496.6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
06
引用
收藏
页数：1
相关论文
共 47 条
  • [31] Reduced rapid delayed rectifier (Ixr) and inward rectifier current (Ix1) contribute action potential prolongation and diastolic depolarization in a chronic canine heart failure model
    Sridhar, Arun
    Nishijima, Yoshinori
    Kijtawornrat, Anusak
    Hamlin, Robert L.
    Carnes, Cynthia A.
    CIRCULATION, 2006, 114 (18) : 8 - 8
  • [32] Adrenergic prolongation of action potential duration in rainbow trout myocardium via inhibition of the delayed rectifier potassium current, IKr
    Abramochkin, Denis, V
    Haworth, T. Eliot
    Kuzmin, Vladislav S.
    Dzhumaniiazova, Irina
    Pustovit, Ksenia B.
    Gacoin, Maeva
    Shiels, Holly A.
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 2022, 267
  • [33] Novel transient outward and ultra-rapid delayed rectifier current antagonist, AVE0118, protects against ventricular fibrillation induced by myocardial ischemia
    Billman, George E.
    Kukielka, Monica
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2008, 51 (04) : 352 - 358
  • [34] Regional differences in the role of the rapid delayed rectifier K+ current, iK,r, within the rabbit sinoatrial node
    Boyett, MR
    Kodama, I
    Nikmaram, MR
    Yamamoto, M
    Honjo, H
    Niwa, R
    Zhang, H
    Holden, AV
    JOURNAL OF PHYSIOLOGY-LONDON, 1998, 511P : 79P - 79P
  • [35] Involvement of Src kinase in the down-regulation of ultra-rapid delayed rectifier K+ current induced by tumor necrosis factor-α in cardiomyocytes
    周慧珊
    China Medical Abstracts(Internal Medicine), 2020, 37 (03) : 166 - 166
  • [36] Role of slow delayed rectifier K+-current in QT prolongation in the alloxan-induced diabetic rabbit heart
    Lengyel, Cs.
    Virag, L.
    Kovacs, P. P.
    Kristof, A.
    Pacher, P.
    Kocsis, E.
    Koltay, Zs. M.
    Nanasi, P. P.
    Toth, M.
    Kecskemeti, V.
    Papp, J. Gy.
    Varro, A.
    Jost, N.
    ACTA PHYSIOLOGICA, 2008, 192 (03) : 359 - 368
  • [37] REDUCED DELAYED RECTIFIER POTASSIUM CURRENT CAUSES ACTION-POTENTIAL PROLONGATION IN HYPERTROPHIED FELINE LEFT-VENTRICULAR MYOCYTES
    NUSS, B
    HOUSER, SR
    CIRCULATION, 1990, 82 (04) : 522 - 522
  • [38] Orange flavonoid Hesperetin prolonged action potential duration and inhibits the slow delayed rectifier potassium current (IKs) in dog and rabbit cardiac ventricular muscle preparations and isolated myocytes
    Mohammed, Aiman
    Naveed, Muhammad
    Topal, Leila
    Mohacsi, Gabor
    Prorok, Janos
    Baczko, Istvan
    Virag, Laszl
    Jost, Norbert
    Varro, Andras
    BRITISH JOURNAL OF PHARMACOLOGY, 2023, 180 : 165 - 165
  • [39] Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart
    Schultz Hansen, Rie
    Olesen, Soren-Peter
    Grunnet, Morten
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2007, 321 (03): : 996 - 1002
  • [40] Time course and voltage dependence of expressed HERG current compared with native ”rapid” delayed rectifier K current during the cardiac ventricular action potential
    J. C. Hancox
    Allan J. Levi
    Harry J. Witchel
    Pflügers Archiv, 1998, 436 : 843 - 853
12345