7-chlorokynurenic acid prevents in vitro epileptiform and neurotoxic effects due to kainic acid

被引：6
|
作者：
Domenici, MR [1 ]
Longo, R [1 ]
Sagratella, S [1 ]
机构：
[1] IST SUPER SANITA,FARMACOL LAB,I-00161 ROME,ITALY
来源：
GENERAL PHARMACOLOGY | 1996年 / 27卷 / 01期
关键词：
7-chlorokynurenic acid; non-NMDA receptors; hippocampal slices; electrophysiology;
D O I：
10.1016/0306-3623(95)00124-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The effects of 7-chlorokynurenic acid were studied against the epileptiform and neurotoxic toxic effects due to the non NMDA excitatory amino acid, kainic acid, in rat hippocampal slices. 2. Slice perfusion with 7-chlorokynurenic acid (100 mu M), significantly (p < 0.05) decreased the duration of the CA1 epileptiform bursting due to 1 mu M kainic acid. 3. Slice perfusion with 7-chlorokynurenic acid(100 mu M) significantly (p < 0.05) increased the probability of recovery of the CA1 population spike after a neurotoxic concentration (12 mu M) of kainic acid. 4. The results indicate that 7-chlorokynurenic acid affects, with a similar potency, epileptiform and neurotoxic effects due to kainic acid.
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页码：113 / 116
页数：4
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