Pyridoxine hydrochloride treatment of carpal tunnel syndrome: A review

It has been hypothesized that idiopathic carpal tunnel syndrome (CTS) is a manifestation. of vitamin B-6 deficiency. Some claim that B-6 supplementation can alleviate symptoms. Others argue that pain relief occurs because of vitamin B-6's anti-nociceptive properties or because B-6 supplementation addresses an unrecognized peripheral neuropathy. Few studies on CTS. and B-6 employed electrodiagnostic techniques in diagnosis, and few showed a correlation between symptoms and improved electrodiagnostic parameters with supplementation. Other studies failed to measure or estimate B-6 levels. Nevertheless, it appears reasonable. to recommend vitamin B-6 supplementation to people with CTS. Some patients will improve symptomatically with low risks of toxicity in recommended doses.