Preparation of poly(styrene-alt-maleic anhydride) grafted multi-walled carbon nanotubes for pH-responsive release of doxorubicin

被引：13
|
作者：
Le, Cuong M. Q. [1 ]
Cao, Xuan Thang [1 ]
Kim, Dong Woo [1 ]
Ban, Uk Hyeon [1 ]
Lee, Sang Ho [1 ]
Lim, Kwon Taek [1 ]
机构：
[1] Pukyong Natl Univ, Dept Display Engn, 599-1 Daeyeon 3 Dong, Busan 608737, South Korea
来源：
MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 2017年 / 654卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
Doxorubicin; drug release; hydrazone bond; multi-walled carbon nanotubes; pH-responsive; RAFT polymerization; FUNCTIONAL POLYMERS; DELIVERY; DRUG; PERFORMANCE; CHEMISTRY;
D O I：
10.1080/15421406.2017.1358041
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A pH-responsive drug release system based on doxorubicin conjugated poly(styrene-alt-maleic anhydride) grafted multi-walled carbon nanotubes (MWNT/PSMA-DOX) was prepared by the reversible addition-fragmentation chain transfer (RAFT) polymerization and acid-cleavable hydrazone linkages. Firstly, multi-walled carbon nanotubes (MWNTs) were modified with a furfuryl derivative RAFT agent by Diels-Alder reaction. The polymerization of styrene and maleic anhydride was carried out in the presence of functionalized MWNTs to afford MWNT/PSMA. The maleic anhydride ring located along the polymer chains was opened by hydrazine subsequently conjugated with doxorubicin via an acid-sensitive hydrazone bond. The composite materials were characterized by FT-IR, H-1-NMR, TGA and TEM analysis. In vitro experiments showed a burst release of doxorubicin at pH 5.0 whereas slight release at pH 7.4.
引用
收藏
页码：181 / 189
页数：9
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