Inhibition of angiogenesis by the BTB domain of promyelocytic leukemia zinc finger protein

被引：7
|
作者：
Rho, Seung Bae [1 ]
Choi, Kyusam [2 ,4 ]
Park, Kyoungsook [2 ]
Lee, Je-Ho [2 ,3 ]
机构：
[1] Natl Canc Ctr, Res Inst, Goyang Si 410769, Gyeonggi Do, South Korea
[2] Sungkyunkwan Univ, Mol Therapy Res Ctr, Canc Ctr B4 193, Samsung Med Ctr, Seoul 135710, South Korea
[3] Sungkyunkwan Univ, Sch Med, Dept Obstet & Gynecol, Samsung Med Ctr,Div Gynecol Oncol, Seoul 135710, South Korea
[4] Yonsei Univ, Coll Sci & Technol, Div Biol Sci & Technol, Wonju 220710, Gangwon Do, South Korea
来源：
CANCER LETTERS | 2010年 / 294卷 / 01期
关键词：
Angiogenesis; BTB/POZ domain; Crystal-based structure; Anti-angiogenic protein; Therapeutic target; NON-HODGKINS-LYMPHOMA; TRANSCRIPTIONAL REPRESSOR; HISTONE DEACETYLASE; UBIQUITIN LIGASES; PLZF PROTEIN; RAR-ALPHA; BCL-6; GENE; REARRANGEMENTS; DROSOPHILA;
D O I：
10.1016/j.canlet.2010.01.021
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Promyelocytic leukemia zinc finger is a negative regulator of cell cycle progression. In this study, we showed that PLZF inhibits endothelial cell angiogenesis using a human umbilical vein endothelial cell system. We also focused on characterizing the specific function of the BTB domain of PLZF as a novel apoptotic and anti-angiogenic protein via deletion mapping analysis. The BTB domain directly inhibited tube formation, as well as the biological functions of angiostatic activity in vivo, and reduced the expression of p-Akt and p-eNOS, which play a significant role in angiogenesis when stimulated by VEGF. These results strongly suggest that the BTB domain could potentially modulate the apoptotic and anti-angiogenic effects of PLZF. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：49 / 56
页数：8
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