Blood Clusterin Levels, rs9331888 Polymorphism, and the Risk of Alzheimer's Disease

被引：46
|
作者：
Xing, Yao-Yao [1 ]
Yu, Jin-Tai [1 ,2 ]
Cui, Wei-Zhen [3 ]
Zhong, Xiao-Ling [1 ]
Wu, Zhong-Chen [1 ]
Zhang, Qun [1 ]
Tan, Lan [1 ,2 ]
机构：
[1] Qingdao Univ, Sch Med, Qingdao Municipal Hosp, Dept Neurol, Qingdao 266071, Peoples R China
[2] Ocean Univ China, Coll Med & Pharmaceut, Qingdao, Peoples R China
[3] Qingdao Mental Hlth Ctr, Dept Geratol, Qingdao, Peoples R China
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2012年 / 29卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; concentration; clusterin; plasma; polymorphism; GENOME-WIDE ASSOCIATION; PLASMA CLUSTERIN; IDENTIFIES VARIANTS; CLU;
D O I：
10.3233/JAD-2011-111844
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Variants in the clusterin gene have been associated with Alzheimer's disease (AD) through replicated genome-wide studies, but the underlying mechanisms remain unknown. In this study the association of the AD clusterin common risk polymorphism rs9331888 with blood clusterin levels was tested in 104 AD subjects and 104 healthy controls. Blood clusterin levels were significantly elevated in AD patients (p < 0.05). The rs9331888 AD-risk variant was associated with low clusterin mRNA and protein levels in an allele-dose dependent manner in both groups (p < 0.001). This study indicates that the rs9331888 AD-risk variant is associated with low blood clusterin levels.
引用
收藏
页码：515 / 519
页数：5
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