Association of the Alzheimer's Disease Clusterin Risk Allele with Plasma Clusterin Concentration

被引：48

作者：

Schuermann, Britta ^{[1
,2
]}

Wiese, Birgitt ^{[3
]}

Bickel, Horst ^{[4
]}

Weyerer, Siegfried ^{[5
]}

Riedel-Heller, Steffi G. ^{[6
]}

Pentzek, Michael ^{[7
]}

Bachmann, Cadja ^{[8
]}

Williams, Julie ^{[9
]}

van den Bussche, Hendrik ^{[8
]}

Maier, Wolfgang ^{[1
,10
]}

Jessen, Frank ^{[1
,10
]}

机构：

[1] Univ Bonn, Dept Psychiat & Psychotherapy, D-53105 Bonn, Germany

[2] Univ Bonn, Inst Mol Psychiat, D-53105 Bonn, Germany

[3] Hannover Med Sch, Inst Biometr, D-3000 Hannover, Germany

[4] Tech Univ Munich, Dept Psychiat, Munich, Germany

[5] Cent Inst Mental Hlth, D-6800 Mannheim, Germany

[6] Univ Leipzig, Inst Social Med Occupat Hlth & Publ Hlth, Leipzig, Germany

[7] Univ Hosp, Dept Gen Practice, Dusseldorf, Germany

[8] Univ Med Ctr, Dept Primary Med Care, Hamburg, Germany

[9] Cardiff Univ, Sch Med, Dept Psychol Med & Neurol, Med Res Council MRC,Ctr Neuropsychiat Genet & Gen, Cardiff, S Glam, Wales

[10] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2011年 / 25卷 / 03期

关键词：

Alzheimer's disease; clusterin; genome wide association study; risk gene; GENOME-WIDE ASSOCIATION; IDENTIFIES VARIANTS; AMYLOID FORMATION; CLU; TOXICITY; CR-1;

D O I：

10.3233/JAD-2011-110251

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A variant within the clusterin gene has been recently associated with increased risk for Alzheimer's disease (AD) in genome wide association studies. Here we tested the association of the respective single nucleotide polymorphisms (rs11136000) with plasma concentration of clusterin in 67 AD subjects and 191 cognitively unimpaired elderly individuals. We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy individuals (p = 0.011). This effect was numerically also present in the AD patients. We conclude that the rs11136000 AD-risk variant is associated with low clusterin plasma levels.

引用

页码：421 / 424

页数：4

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